country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163062

Copy Link Print Information

Tubulin/NRP1-IN-1

Tubulin/NRP1-IN-1 (compound TN-2) is a dual inhibitor of Tubulin and NRP1 with IC₅₀s of 0.71 and 0.85 μM, respectively. Tubulin/NRP1-IN-1 significantly inhibits the viability of prostate tumor cell lines and induces apoptosis.

For research use only. We do not sell to patients.

CAS No.: 2983719-82-8
Formula: C₂₈H₃₇N₅O₈
Molecular Weight:571.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Tubulin/NRP1-IN-1 Chemical Structure

CAS No.: 2983719-82-8

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC₅₀	0.02 μM Compound: TN-2	Cytotoxicity against human PC-3 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38093696]
PrEC	IC₅₀	>10 μM Compound: TN-2	Cytotoxicity against human PrEC cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human PrEC cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38093696]

Chemical Information

CAS No. 2983719-82-8
Molecular Weight 571.62
Formula C₂₈H₃₇N₅O₈
SMILES

COC1=C(C=C(C=C1OC)/C=C\C2=CC(NC(CCC(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=C(C=C2)OC)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zheng L, et al. Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation. J Med Chem. 2023 Dec 14;66(23):16187-16200. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote