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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Neuropilin-1 Antibody (YA1831)

Neuropilin-1 Antibody (YA1831)

Cat. No.: HY-P82086
User Guide for Antibodies Technical Support

Neuropilin-1 Antibody (YA1831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neuropilin-1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Neuropilin-1 Antibody (YA1831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neuropilin-1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 103 kDa;
Observed band size: 125-135 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Neuropilin 1
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
IP
IP: Immunoprecipitation
1:50
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed:10688880, PubMed:9288753, PubMed:9529250). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799); (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection; Binds VEGF-165 and may inhibit its binding to cells (PubMed:10748121, PubMed:26503042). May induce apoptosis by sequestering VEGF-165 (PubMed:10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity
Subcellular Localization：Secreted; Mitochondrion membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Cytoplasm
Expression：
Tissue_specificity:Expression of isoforms 1 and 2 appears to have no overlap. Expressed in olfactory epithelium (protein level) (PubMed:33082293) . Expressed in fibroblasts (protein level) (PubMed:36213313) . Expressed in blood vessels of various tissues. In developing embryos, primarily present in the nervous system. In adult tissues, highly expressed in the heart and placenta; moderately expressed in the lungs, liver, skeletal muscle, kidneys, and pancreas; and lowly expressed in the adult brain (PubMed:10688880, PubMed:9529250) . Expressed in the central nervous system, including olfactory-related regions such as the olfactory tubercle and paraolfactory gyrus (PubMed:33082293) ; expression of isoforms 1 and 2 appears to have no overlap. Present in hepatocytes of the liver and distal and proximal convoluted tubules of the kidneys.
Isoforms & Post-Translational Modification：O14786 has 3 isomers: O14786-1: 103134 Da (predicted); O14786-2: 71935 Da (predicted); O14786-3: 68376 Da (predicted).
Subunit：Homodimer, and heterodimer with NRP2 (PubMed:17989695). Interacts with FER (By similarity). Interacts with PLXNB1 (PubMed:10520995). Interacts with VEGFA (PubMed:19805273, PubMed:26503042). Interacts with ABCB8/MITOSUR in mitochondria (PubMed:30623799)
Database

Entrez Gene: 8829 Human ; 18186 Mouse ; 246331 Rat

SwissProt: O14786 Human ; P97333 Mouse ; Q9QWJ9 Rat

OMIM: 602069 Human

Research Field

Cardiovascular
Synonyms
NRP1; NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD antigen CD304
Documentation
User Guide for Antibodies (1077 KB)

Neuropilin-1 Antibody (YA1831) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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