Neuropilin-1 Antibody (YA1831)
(Synonyms: NRP1; NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD antigen CD304)Neuropilin-1 Antibody (YA1831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neuropilin-1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 | 1:50 |
Product Details
Neuropilin-1 Antibody (YA1831) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neuropilin-1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 125-135 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 103 kDa
Entrez Gene: 8829 Human ; 18186 Mouse ; 246331 Rat
SwissProt: O14786 Human ; P97333 Mouse ; Q9QWJ9 Rat
OMIM: 602069 Human
A synthesized peptide derived from human Neuropilin 1
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Neuropilin-1 is a Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR; (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection; Binds VEGF-165 and may inhibit its binding to cells. May induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity[1][2][3][4][5][6][7].
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Subcellular Localization
Secreted; Mitochondrion membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Cytoplasm
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Expression
Tissue_specificity:Expression of isoforms 1 and 2 appears to have no overlap. Expressed in olfactory epithelium (protein level) (PubMed:33082293) . Expressed in fibroblasts (protein level) (PubMed:36213313) . Expressed in blood vessels of various tissues. In developing embryos, primarily present in the nervous system. In adult tissues, highly expressed in the heart and placenta; moderately expressed in the lungs, liver, skeletal muscle, kidneys, and pancreas; and lowly expressed in the adult brain (PubMed:10688880, PubMed:9529250) . Expressed in the central nervous system, including olfactory-related regions such as the olfactory tubercle and paraolfactory gyrus (PubMed:33082293) ; expression of isoforms 1 and 2 appears to have no overlap. Present in hepatocytes of the liver and distal and proximal convoluted tubules of the kidneys. -
Isoforms & Post-Translational Modification
O14786 has 3 isomers: O14786-1: 103134 Da (predicted); O14786-2: 71935 Da (predicted); O14786-3: 68376 Da (predicted).
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Subunit
Homodimer, and heterodimer with NRP2 (PubMed:17989695). Interacts with FER (By similarity). Interacts with PLXNB1 (PubMed:10520995). Interacts with VEGFA (PubMed:19805273, PubMed:26503042). Interacts with ABCB8/MITOSUR in mitochondria (PubMed:30623799)
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SwissProt ID
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Synonyms
NRP1; NRP; VEGF165R; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD antigen CD304
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Research Field
Cardiovascular
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