NTD

By Targets:	Androgen Receptor (6) Antibiotic (1) Apoptosis (3) Bacterial (3) Parasite (2) PPAR (1) PROTACs (2)
By Research Areas:	Cancer (6) Infection (5) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109070

Ralaniten EPI-002	Androgen Receptor	Cancer
Ralaniten (EPI-002) is a potent and orally active antagonist of the androgen receptor-N-terminal domain (AR-NTD). Ralaniten inhibits AR transcriptional activity, with IC₅₀ of 7.4 μM. Ralaniten can be used for the research of castration-resistant prostate cancer (CRPC) .

HY-138694

5-Benzyloxygramine

Antibiotic Infection

5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities .

5-Benzyloxygramine	Antibiotic	Infection
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities .

HY-149434

*PROTAC AR-NTD* degrader 1**	Androgen Receptor Apoptosis	Cancer
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule protein-targeting chimera (PROTACs) targeting the Androgen Receptor AR-V7. PROTAC AR-NTD antagonist 1 antagonizes the N-terminal domain of AR (AR-NTD), degrades AR-V7 protein, and induces apoptosis in prostate cancer (PC) cells. The efficiencies of PROTAC AR-NTD antagonist 1 in degrading AR-V7 in VCaP cells were 62.2% (1 μM) and 71.1% (5 μM), respectively .

HY-153572

Homo-BacPROTAC7

PROTACs Bacterial Infection

Homo-BacPROTAC7 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .
HY-153571

Homo-BacPROTAC6

PROTACs Bacterial Infection

Homo-BacPROTAC6 is a ClpC1_NTD BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

Homo-BacPROTAC7	PROTACs Bacterial	Infection
Homo-BacPROTAC7 is a *ClpC1_NTD* BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

Homo-BacPROTAC6	PROTACs Bacterial	Infection
Homo-BacPROTAC6 is a *ClpC1_NTD* BacPROTAC degrader and can targets ClpC2. Homo-BacPROTAC7 efficiently kill M. tuberculosis .

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Others	Neurological Disease Metabolic Disease
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

HY-110104

8MDP	Others	Others
8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC₅₀ of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H ³] uridine by K562 cells and K15NTD cells .

HY-123875A

Ralaniten triacetate EPI-506	Androgen Receptor	Cancer
Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7 .

HY-155846

Antileishmanial agent-22	Parasite Bacterial	Infection
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC₅₀=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC₅₀), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .

HY-155845

Antileishmanial agent-21	Parasite	Infection
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC₅₀ of 0.0198-0.096 μM .

HY-155478

Androgen receptor-IN-6	Androgen Receptor	Cancer
Androgen receptor-IN-6 (compound 16) is an orally available androgen receptor (Androgen Receptor) potent inhibitor (IC₅₀=0.12 μM in vitro), targeting the disordered N-terminal domain (NTD). Androgen receptor-IN-6 has good Caco2 cell membrane permeability and has an oral activity (F/%) of 16% in male CD-1 mice .

HY-100348

EPI-001
EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC₅₀ of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .

HY-100348R

EPI-001 (Standard)	Androgen Receptor PPAR Apoptosis	Cancer
EPI-001 (Standard) is the analytical standard of EPI-001. This product is intended for research and analytical applications. EPI-001, a selective inhibitor of Androgen Receptor (AR), targets transactivation unit 5 (Tau-5) of the AR. EPI-001 can inhibit transactivation of the AR amino-terminal domain (NTD), with an IC₅₀ of ~6 μM. EPI-001 is also a selective modulator of PPARγ. EPI-001 is active against castration-resistant prostate cancer .

HY-149433

BWA-522	Androgen Receptor Apoptosis	Cancer
BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor) and induces apoptosis in PC cells. BWA-522 inhibits tumor growth in LNCaP xenograft model studies (60 mg/kg, po; TGI=76%). The efficiencies of BWA-522 in degrading AR-V7 and AR-FL were 77.3% (1 μM) and 72.0% (5 μM) in VCaP and LNCaP cells, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0430B

(±)-Pantothenic acid (±)-Pantothenate; (±)-Vitamin B5	Other disease Disease markers Endogenous metabolite	Others
(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice .

Species:	Virus (5)
Tag:	His (5) Tag Free (1) Avi (3) Flag (1) Fc (1)
Source:	HEK293 (3) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P78280

	*SARS-COV-2 S1 Protein NTD* (HEK293, His-Flag)** S1 protein NTD,Spike glycoprotein Subunit1 NTD,S glycoprotein Subunit1 NTD,Spike protein S1 NTD	Virus	HEK293
	SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-COV-2 S1 Protein NTD (HEK293, His-Flag) is the recombinant Virus-derived SARS-COV-2 S1 protein NTD, expressed by HEK293 , with C-His, C-Flag labeled tag. The total length of SARS-COV-2 S1 Protein NTD (HEK293, His-Flag) is 290 a.a., with molecular weight of 55-70 kDa.

HY-P76047

	*SARS-CoV-2 S1 Protein NTD* (Biotinylated, HEK293, Fc-Avi)** SARS-CoV-2 (2019-nCoV) Spike S1 NTD Protein	Virus	HEK293
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein NTD (Biotinylated, HEK293, Fc-Avi) is the recombinant Virus-derived SARS-CoV-2 S1 protein NTD, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of SARS-CoV-2 S1 Protein NTD (Biotinylated, HEK293, Fc-Avi) is 290 a.a., with molecular weight of ~61.74 kDa.

HY-P78186

	*SARS-CoV-2 Nucleocapsid Protein NTD* domain (His-Avi)** Nucleocapsid; NP; NC	Virus	E. coli
	SARS-CoV-2 S1 Protein, in its Spike protein S1 form, initiates infection by attaching the virion to the cell membrane through host receptor interaction. Simultaneously, Spike protein S2' acts as a viral fusion peptide, revealing itself after S2 cleavage during virus endocytosis. SARS-CoV-2 Nucleocapsid Protein NTD domain (His-Avi) is the recombinant Virus-derived SARS-CoV-2 Nucleocapsid protein NTD domain, expressed by E. coli , with N-His, N-Avi labeled tag. The total length of SARS-CoV-2 Nucleocapsid Protein NTD domain (His-Avi) is 117 a.a., with molecular weight of ~16.3 kDa.

HY-P701867

	*ClpC1 NTD* Protein, Mycobacterium tuberculosis** clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis is the recombinant ClpC1 NTD protein, expressed by E. coli , with tag free. The total length of ClpC1 NTD Protein, Mycobacterium tuberculosis is 145 a.a., .

HY-P701868

	*ClpC1 NTD* Protein, Mycobacterium tuberculosis (His)** clpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1	Others	E. coli
	ClpC1 NTD Protein, the ATP-dependent specificity component of the Clp protease, directs the protease to specific substrates and exhibits chaperone functions independently of ClpP. It plays a crucial role in the targeted degradation of substrates, such as the anti-sigma-E factor RseA, in the presence of ClpP2. ClpC1 NTD Protein, Mycobacterium tuberculosis (His) is the recombinant ClpC1 NTD protein, expressed by E. coli , with N-6*His labeled tag. The total length of ClpC1 NTD Protein, Mycobacterium tuberculosis (His) is 145 a.a., .

HY-P7438

	*Nucleocapsid Protein NTD* domain, Virus (His)** 2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein Protein	Virus	E. coli
	Nucleocapsid Protein NTD domain, Virus (His) is the N-terminal RNA-binding domain (NTD) of nucleocapsid protein in coronaviruses. Nucleocapsid Protein NTD domain has highly conserved residues in the centre, which is identified as the RNA-binding site.

HY-P76629

	*SARS-CoV-2 S1 Protein NTD* (Biotinylated, HEK293, His-Avi)** SARS-CoV-2 (2019-nCoV) Spike Protein; 2019-nCoV Spike Protein	Virus	HEK293
	The SARS-Cov-2 S glycoprotein is a SARS-Cov-2 S glycoprotein. The amino acid sequence 1261-1267a.a of the SARS-Cov-2 S glycoprotein is transmembrane. The SARS-Cov-2 S glycoprotein is a highly glycosylated trimer, each of which consists of 1260 amino acids (residues 14-1273), divided into four structural domains: the n-terminal domain (NTD), the c-terminal domain (CTD, also known as the receptor-binding domain, RBD), and two subdomains (SD1 and SD2). SARS-CoV-2 S1 Protein NTD (Biotinylated, HEK293, His-Avi) is the recombinant Virus-derived SARS-CoV-2 S1 protein NTD, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of SARS-CoV-2 S1 Protein NTD (Biotinylated, HEK293, His-Avi) is 305 a.a., with molecular weight of ~36 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81230

GSDMD Antibody DF 5L; DF5L; DFNA 5L; DFNA5L; FKSG 10; FKSG10; FLJ12150; Gasdermin D; Gasdermin domain containing 1; Gasdermin domain containing protein 1; Gasdermin domain-containing protein 1; Gasdermin-D; GasderminD; GSDMD_HUMAN; GSDMDC 1; GSDMDC1; Gasdermin-D, N-terminal; GSDMD-NT; hGSDMD-NTD; Gasdermin-D, C-terminal; GSDMD-CT; hGSDMD-CTD.	WB; ELISA; IHC-P; IHC-F; ICC; IF	Human(predicted: Mouse, Rat)
GSDMD Antibody is an unconjugated, approximately 53 kDa, rabbit-derived, anti-GSDMD polyclonal antibody. GSDMD Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, and predicted: mouse, rat background without labeling.

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