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Ralaniten triacetate (Synonyms: EPI-506)

Cat. No.: HY-123875A
Handling Instructions

Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7.

For research use only. We do not sell to patients.

Ralaniten triacetate Chemical Structure

Ralaniten triacetate Chemical Structure

CAS No. : 1637573-04-6

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Description

Ralaniten triacetate (EPI-506), the pro-drug of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7[1][2].

In Vitro

Ralaniten triacetate (EPI-506) targets the N-terminal domain of the androgen receptor (AR), and is used for metastatic castration-resistant prostate cancer (mCRPC) research. EPI-506 is a first-in-class, highly-specific small molecule that binds to a novel target on the AR, the N-terminal domain (NTD) and directly inhibits AR transcriptional activity by blocking the interaction of the AR with transcriptional proteins[2].

Molecular Weight

521.00

Formula

C₂₇H₃₃ClO₈

CAS No.

1637573-04-6

SMILES

CC(C(C=C1)=CC=C1OC[[email protected]@H](CCl)OC(C)=O)(C(C=C2)=CC=C2OC[[email protected]](OC(C)=O)COC(C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ralaniten triacetateEPI-506EPI506EPI 506Androgen ReceptorprodrugAR-v7speciesN-terminaldomainprostatecancerInhibitorinhibitorinhibit

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