1637573-04-6
Chemical Structure
Ralaniten triacetate
Synonym(s): EPI-506
- CAS No.: 1637573-04-6
- Formula:C27H33ClO8
- Molecular Weight:521.00
IUPAC Name: (S)-3-(4-(2-(4-((S)-2-acetoxy-3-chloropropoxy)phenyl)propan-2-yl)phenoxy)propane-1,2-diyl diacetate
InChIKey: HGHVYYKTOXUQNT-CLJLJLNGSA-N
SMILES: CC(C(C=C1)=CC=C1OC[C@@H](CCl)OC(C)=O)(C(C=C2)=CC=C2OC[C@H](OC(C)=O)COC(C)=O)C
Biological Activity: Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7[1][2].
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Ralaniten triacetate | 98.79% | Ralaniten triacetate (EPI-506), the pro-agent of Ralaniten, is a first-in-class, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate shows activity against both full length and resistance-related AR species, including AR-v7. | ||||||||||||||||||||
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- [1]. Obst JK, et al. Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies. ACS Pharmacol Transl Sci. 2019;2(6):453-467. Published 2019 Sep 26. [Content Brief]
- [2]. Chi, Kim Nguyen et al. Efficacy, safety, tolerability, and pharmacokinetics of EPI-506 (ralaniten acetate), a novel androgen receptor (AR) N-terminal domain (NTD) inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC) progressing after enzalutamide and/or abiraterone. Journal of Clinical Oncology 35 (2017): 5032-5032.
Keywords
