2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Androgen Receptor Apoptosis
  4. BWA-522

BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor) and induces apoptosis in PC cells. BWA-522 inhibits tumor growth in LNCaP xenograft model studies (60 mg/kg, po; TGI=76%). The efficiencies of BWA-522 in degrading AR-V7 and AR-FL were 77.3% (1 μM) and 72.0% (5 μM) in VCaP and LNCaP cells, respectively.

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BWA-522 Chemical Structure

BWA-522 Chemical Structure

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5 mg USD 935 In-stock
10 mg USD 1500 In-stock
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Based on 1 publication(s) in Google Scholar

BWA-522 Related Antibodies

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Description

BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor) and induces apoptosis in PC cells. BWA-522 inhibits tumor growth in LNCaP xenograft model studies (60 mg/kg, po; TGI=76%). The efficiencies of BWA-522 in degrading AR-V7 and AR-FL were 77.3% (1 μM) and 72.0% (5 μM) in VCaP and LNCaP cells, respectively[1].

Molecular Weight

771.34

Formula

C43H51ClN4O7
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1=CC=C(OC[C@H](O)CCl)C=C1)(C)C(C=C2)=CC=C2OCC3CCN(CC4CCN(C5=CC=C6C(C(N(C7CCC(NC7=O)=O)C6=O)=O)=C5)CC4)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 90 mg/mL (116.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2964 mL 6.4822 mL 12.9645 mL
5 mM 0.2593 mL 1.2964 mL 2.5929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2964 mL 6.4822 mL 12.9645 mL 32.4111 mL
5 mM 0.2593 mL 1.2964 mL 2.5929 mL 6.4822 mL
10 mM 0.1296 mL 0.6482 mL 1.2964 mL 3.2411 mL
15 mM 0.0864 mL 0.4321 mL 0.8643 mL 2.1607 mL
20 mM 0.0648 mL 0.3241 mL 0.6482 mL 1.6206 mL
25 mM 0.0519 mL 0.2593 mL 0.5186 mL 1.2964 mL
30 mM 0.0432 mL 0.2161 mL 0.4321 mL 1.0804 mL
40 mM 0.0324 mL 0.1621 mL 0.3241 mL 0.8103 mL
50 mM 0.0259 mL 0.1296 mL 0.2593 mL 0.6482 mL
60 mM 0.0216 mL 0.1080 mL 0.2161 mL 0.5402 mL
80 mM 0.0162 mL 0.0810 mL 0.1621 mL 0.4051 mL
100 mM 0.0130 mL 0.0648 mL 0.1296 mL 0.3241 mL
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BWA-522 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BWA-522BWA522BWA 522Androgen ReceptorApoptosisPROTACprostatic cancerVCaPLNCaPInhibitorinhibitorinhibit

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