Antileishmanial agent-22
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM.
For research use only. We do not sell to patients.
- Formula: C29H26Cl2N4O3
- Molecular Weight:549.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.408 μM (leishmanial), 0.038 μM (P. berghei); MIC: 28.44 μM (M. tuberculosis)[1]
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Cell Line
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Type | Value | Description | References |
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| Vero | CC50 |
455 μM
Compound: 15b
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Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
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[PMID: 37269671] |
Chemical Information
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Molecular Weight 549.45
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Formula C29H26Cl2N4O3
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SMILES
O=C(C1CCN(C(C)=O)CC1)NCC2=CC=C3CCC4=C(NC(C(C#N)=C4C5=C(Cl)C=CC(Cl)=C5)=O)C3=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-22 Related Classifications
HY-155846 Related Classifications
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