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Art. -Nr.: HY-149434

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PROTAC AR-NTD degrader 1

PROTAC AR-NTD degrader 1 is a PROTAC degrader that recruits cereblon and targets the N-terminal domain of the androgen receptor (AR-NTD), thereby inducing the degradation of AR-FL and AR-V7 proteins. PROTAC AR-NTD degrader 1 can be used for studies related to androgen receptor degradation and prostate cancer.
(Pink: Androgen Receptor ligand (HY-109070); Blue: Cereblon ligand (HY-14658); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3032601-92-3
Formel: C₄₁H₄₇ClN₆O₇
Molecular Weight:771.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC AR-NTD degrader 1 Chemical Structure

CAS. Nr.: 3032601-92-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

PROTAC AR-NTD degrader 1 is a PROTAC degrader that recruits cereblon and targets the N-terminal domain of the androgen receptor (AR-NTD), thereby inducing the degradation of AR-FL and AR-V7 proteins. PROTAC AR-NTD degrader 1 can be used for studies related to androgen receptor degradation and prostate cancer^[1]. (Pink: Androgen Receptor ligand (HY-109070); Blue: Cereblon ligand (HY-14658); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancer

PROTAC AR-NTD degrader 1 (compound 18) (1-5 μM) reduces AR-FL protein levels by <5.0% and 28.6%, respectively, in LNCaP cells^[1].
PROTAC AR-NTD degrader 1 (1-5 μM) reduces AR-FL protein levels by 15.3% and 23.3%, respectively, and decreases AR-V7 protein levels by 62.2% and 71.1%, respectively, in VCaP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Endocrine Diseases

Chemical Information

CAS. Nr. 3032601-92-3
Molecular Weight 771.30
Formel C₄₁H₄₇ClN₆O₇
SMILES

O=C(N1)CCC(N2C(C3=CC=C(C=C3C2=O)NCCCN4N=NC(CCCCCOC5=CC=C(C(C)(C)C6=CC=C(OC[C@@H](CCl)O)C=C6)C=C5)=C4)=O)C1=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang B, et al. Discovery of , a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. Journal of medicinal chemistry. 2023 Aug 24;66(16):11158-11186. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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