Antileishmanial agent-21
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM.
For research use only. We do not sell to patients.
- Formula: C21H16N2O3
- Molecular Weight:344.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Leishmania major pteridine reductase 1, Lm-PTR1[1]
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Cell Line
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Type | Value | Description | References |
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| Vero | CC50 |
362.9 μM
Compound: 4e
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Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
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[PMID: 37269671] |
Chemical Information
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Molecular Weight 344.36
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Formula C21H16N2O3
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SMILES
OC(C(OC)=C1)=CC=C1C(C2=C(C3=CC=CC=C3CC2)NC4=O)=C4C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-21 Related Classifications
HY-155845 Related Classifications
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