2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-21

Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM.

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Antileishmanial agent-21

Antileishmanial agent-21 Chemical Structure

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Antileishmanial agent-21 Related Antibodies

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Description

Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM[1].

IC50 & Target

Leishmania major pteridine reductase 1, Lm-PTR1[1]
Cellular Effect
Cell Line Type Value Description References
Vero CC50
362.9 μM
Compound: 4e
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
[PMID: 37269671]
Molecular Weight

344.36

Formula

C21H16N2O3
SMILES

OC(C(OC)=C1)=CC=C1C(C2=C(C3=CC=CC=C3CC2)NC4=O)=C4C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antileishmanial agent-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-21Antileishmanial agent21Antileishmanial agent 21ParasiteLeishmaniaMDMalariaNTDOne-potTuberculosistetrahydrobenzo[h]quinolineInhibitorinhibitorinhibit

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