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Results for "

New Delhi Metallo-β-lactamase-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (5) Antibiotic (2) Bacterial (10) Beta-lactamase (9) Endogenous Metabolite (2) Environmental Pollutants (1) Isotope-Labeled Compounds (2) Reference Standards (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (5) Infection (11) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-B0368

Captopril 20+ Cited Publications SQ 14225	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Endogenous Metabolite	Metabolic Disease
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-B0368R

Captopril (Standard) SQ 14225 (Standard)	Reference Standards Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril (Standard) is the analytical standard of Captopril. This product is intended for research and analytical applications. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM .

HY-B0967

Phthalylsulfacetamide	Antibiotic Bacterial	Infection
Phthalylsulfacetamide is an orally active sulfonamide antibiotic and **New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀** of 15.4 μM. Phthalylsulfacetamide stably binds to the active hydrolysis center of NDM-1, interacts with Zn²⁺, and interacts with key amino acid residues Val73 and His122 to inhibit enzyme activity. Phthalylsulfacetamide can be used for the research of Escherichia coli infection .

HY-155283

Zndm19	Beta-lactamase Bacterial	Infection
Zndm19 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor. Zndm19 can be used for the research of drug-resistant bacterial infections .

HY-150758

NDM-1 inhibitor-3	Beta-lactamase Bacterial	Infection
NDM-1 inhibitor-3 (Compound 89) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a K_i of 4 μM .

HY-178019

NDM-1-IN-10	Beta-lactamase Bacterial	Infection
NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 36  nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli ( MIC of 0.25 μg/mL for E. coli BL21/pET15b-bla_NDM-1). NDM-1-IN-10 can be used for bacterial infections research .

HY-162493

MBL-IN-3	Bacterial	Infection
MBL-IN-3 (compound 72922413) is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor(IC₅₀=54±4 μM). MBL-IN-3 is identified and shown to lower minimum inhibitory concentrations (MICs) of Meropenem (HY-13678) for a panel of E. coli and K. pneumoniae clinical isolates expressing NDM-1. MBL-IN-3 can be used for antibiotic sensitizer research .

HY-155202

YJ196	Beta-lactamase	Others
YJ196 (Compound 59) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor .

HY-B0368A

Captopril hydrochloride SQ 14225 hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-162174

MBL-IN-2	Beta-lactamase Bacterial	Infection
MBL-IN-2 ((2R, 2R')-5αC) is an inhibitor of Metallo-β-lactamase (MBL) that can inhibit New Delhi Metallo-β-lactamase-1 (NDM-1) with an IC₅₀ of 0.3 μM. MBL-IN-2 ((2R, 2R')-5αC) can be used for the study of resistance to β-lactam antibiotics .

HY-B0368S

Captopril-d3 SQ 14225-d₃	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-168861

NDM-1 inhibitor-8	Beta-lactamase Bacterial	Infection
NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for **new delhi metallo-β-lactamase-1 (NDM-1) with an IC₅₀** of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models .

HY-118013

NDM-1 inhibitor-2	Bacterial	Infection
NDM-1 inhibitor-2 is an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) and has the ability to inhibit NDM-1 activity. NDM-1 inhibitor-2 exhibits a good inhibitory effect on drug-resistant bacterial strains that overexpress NDM-1. When NDM-1 inhibitor-2 is used in combination with the carbapenem antibiotic meropenem, a favorable synergistic effect can be produced .

HY-B0368S1

Captopril-13C5,15N SQ 14225-¹³C₅,¹⁵N	Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-122262

NDM-1-IN-6	Beta-lactamase Bacterial	Infection
NDM-1-IN-6 (Compound 1) is a potent, selective and competitive **New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a K_i** of 0.72 μM. NDM-1-IN-6 has a synergistic antibacterial effect with the carbapenem antibiotic Meropenem (HY-13678). NDM-1-IN-6 is mainly used for research on NDM-1-mediated multidrug-resistant bacterial infections .

HY-W140346

Copper(II) pyrithione	Environmental Pollutants Beta-lactamase	Infection Cancer
Copper (II) pyrithione is a **New Delhi metallo-β-lactamase 1 inhibitor. Copper (II) pyrithione inhibits New Delhi metallo-β-lactamase 1** via transmetallation of its zinc (II) cofactor with copper (II). Copper (II) pyrithione exerts cytotoxic effects on pancreatic cancer cells and osteosarcoma cells. Copper (II) pyrithione exhibits antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria. Copper (II) pyrithione can synergistically enhance the activity of β-lactam antibiotics against β-lactam-resistant bacteria. Copper (II) pyrithione can be used in studies related to pancreatic cancer, osteosarcoma and bacterial infections .

HY-183935

NDM-1-IN-13	Beta-lactamase Antibiotic Bacterial	Infection
NDM-1-IN-13 is a NDM-1 inhibitor with an IC₅₀ of 3.27 μM. As an Antibiotic synergist, NDM-1-IN-13 synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-positive bacterial isolates. NDM-1-IN-13 can be used in studies related to NDM-1-positive bacterial infections .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-121765

Dacisteine N,S-Diacetyl-L-cysteine	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

HY-121765R

Dacisteine (Standard) N,S-Diacetyl-L-cysteine (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Dacisteine (Standard) is the analytical standard of Dacisteine. This product is intended for research and analytical applications. Dacisteine (N,S-Diacetyl-L-cysteine) is a cysteine derivative and displays a less New Delhi metallo-beta-lactamase-1 (NDM-1) inhibitor with an IC₅₀ value of 1000 μM . Dacisteine can be used for the treatment of cardiovascular and cerebrovascular diseases caused by platelet aggregation .

Cat. No.	상품명	Chemical Structure

HY-B0368S

Captopril-d3
Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

Captopril-d3

Captopril-d₃ is deuterium labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

HY-B0368S1

Captopril-13C5,15N
Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

Captopril-13C5,15N

Captopril- ¹³C₅, ¹⁵N (SQ 14225- ¹³C₅, ¹⁵N) is ¹³C and ¹⁵N labeled Captopril. Captopril (SQ 14225), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM .

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