NDM-1-IN-13 

NDM-1-IN-13 is a NDM-1 inhibitor with an IC₅₀ of 3.27 μM. As an Antibiotic synergist, NDM-1-IN-13 synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-positive bacterial isolates. NDM-1-IN-13 can be used in studies related to NDM-1-positive bacterial infections^[1].

NDM-1-IN-13 (Compound 16a) inhibits NDM-1 with an IC₅₀ value of 3.27 μM^[1].
Combination of NDM-1-IN-13 with Meropenem (HY-13678) synergistically reduces the MIC of Meropenem (by 8- to 16-fold) against NDM-1-positive isolates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Combination treatment with NDM-1-IN-13 (32 mg/kg; i.p.) and Meropenem significantly improves the survival rate of mice infected with Escherichia coli EC53, and restores the antibacterial effect of Meropenem against NDM-1-positive Escherichia coli EC53^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

395.29

C₁₅H₁₂N₂O₄SSe

O=C(O)C1=C(C)CS[C@](N1C2=O)([H])[C@@H]2N3[Se]C4=CC=CC=C4C3=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu W, et al. The New Delhi Metallo-β-lactamase-1 Covalent Inhibitors Derived from Cephalexin Effectively Reverse Meropenem Resistance. J Med Chem. 2026;69(10):12398-12416.