NDM-1 inhibitor-8
NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models.
For research use only. We do not sell to patients.
- Formula: C28H23Cl2N3O4SSe
- Molecular Weight:647.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Beta-lactamase Isoforms
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Biological Activity
Chemical Information
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Molecular Weight 647.43
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Formula C28H23Cl2N3O4SSe
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SMILES
O=C(NC1=CC=CC=C1)C2=C([Se]CC3=C(C(O)=O)N(C([C@H]4NCC5=CC(Cl)=CC(Cl)=C5)=O)[C@]4([H])SC3)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)