Copper(II) pyrithione
Based on 1 Customer Validation
Copper (II) pyrithione is a New Delhi metallo-β-lactamase 1 inhibitor. Copper (II) pyrithione inhibits New Delhi metallo-β-lactamase 1 via transmetallation of its zinc (II) cofactor with copper (II). Copper (II) pyrithione exerts cytotoxic effects on pancreatic cancer cells and osteosarcoma cells. Copper (II) pyrithione exhibits antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria. Copper (II) pyrithione can synergistically enhance the activity of β-lactam antibiotics against β-lactam-resistant bacteria. Copper (II) pyrithione can be used in studies related to pancreatic cancer, osteosarcoma and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 14915-37-8
- Formula: C10H8CuN2O2S2
- Molecular Weight:315.86
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Copper(II) pyrithione (24 h) inhibits proliferation of MIA PaCa-2 pancreatic carcinoma cells with an IC50 of 0.15 μM, 143B bone osteosarcoma cells with an IC50 of 0.20 μM, and ARPE-19 normal retinal epithelial cells with an IC50 of 0.22 μM following 24 h incubation[1].
Copper(II) pyrithione (1 μM; 4 h) exhibits a cell uptake of 16 ng of Cu per 106 143B bone osteosarcoma cells following 4 h incubation[1].
Copper(II) pyrithione inhibits growth of Staphylococcus aureus ATCC 29213 with an MIC of 0.4 μM, Escherichia coli ATCC 25922 with an MIC of 6.4 μM, Klebsi pneumoniae BAA 1705 with an MIC of 12.8 μM, and Acinetobacter baumannii BAA 1605 with an MIC of 12.8 μM, with no activity against Pseudomonas aeruginosa ATCC 27853 up to 100 μM[1].
Copper(II) pyrithione (25 μM) reduces the MIC of meropenem and ertapenem by 10-fold against NDM-1-producing β-lactam-resistant Escherichia coli, enhancing the antibiotics' potency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 14915-37-8
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Appearance Solid
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Molecular Weight 315.86
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Formula C10H8CuN2O2S2
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Color Green to dark green
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SMILES
N12[O-][Cu+2]3([O-]N4C=CC=CC4=[S]3)[S]=C1C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (581 KB)
- English - EN (581 KB)
- Français - FR (581 KB)
- Deutsch - DE (581 KB)
- Norwegian - NO (581 KB)
- Español - ES (581 KB)
- Swedish - SV (581 KB)
- Italian - IT (581 KB)
- Korean - KR (581 KB)
- Portuguese - PT (581 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Copper(II) pyrithione Related Classifications
HY-W140346 Related Classifications
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- Copper(II) pyrithione
- 14915-37-8
- Environmental Pollutants
- Beta-lactamase
- β-lactam antibiotics
- 143B bone osteosarcoma cells
- pancreatic carcinoma cells
- Gram-positive bacteria
- zinc(II) cofactor
- New Delhi metallo-β-lactamase 1
- Gram-negative bacteria
- copper(II)
- MIA PaCa-2 pancreatic carcinoma cells
- bone osteosarcoma cells
- Inhibitor
- inhibitor
- inhibit