Copper(II) pyrithione 

Copper (II) pyrithione is a New Delhi metallo-β-lactamase 1 inhibitor. Copper (II) pyrithione inhibits New Delhi metallo-β-lactamase 1 via transmetallation of its zinc (II) cofactor with copper (II). Copper (II) pyrithione exerts cytotoxic effects on pancreatic cancer cells and osteosarcoma cells. Copper (II) pyrithione exhibits antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria. Copper (II) pyrithione can synergistically enhance the activity of β-lactam antibiotics against β-lactam-resistant bacteria. Copper (II) pyrithione can be used in studies related to pancreatic cancer, osteosarcoma and bacterial infections^[1].

Copper(II) pyrithione (24 h) inhibits proliferation of MIA PaCa-2 pancreatic carcinoma cells with an IC₅₀ of 0.15 μM, 143B bone osteosarcoma cells with an IC₅₀ of 0.20 μM, and ARPE-19 normal retinal epithelial cells with an IC₅₀ of 0.22 μM following 24 h incubation^[1].
Copper(II) pyrithione (1 μM; 4 h) exhibits a cell uptake of 16 ng of Cu per 10⁶ 143B bone osteosarcoma cells following 4 h incubation^[1].
Copper(II) pyrithione inhibits growth of Staphylococcus aureus ATCC 29213 with an MIC of 0.4 μM, Escherichia coli ATCC 25922 with an MIC of 6.4 μM, Klebsi pneumoniae BAA 1705 with an MIC of 12.8 μM, and Acinetobacter baumannii BAA 1605 with an MIC of 12.8 μM, with no activity against Pseudomonas aeruginosa ATCC 27853 up to 100 μM^[1].
Copper(II) pyrithione (25 μM) reduces the MIC of meropenem and ertapenem by 10-fold against NDM-1-producing β-lactam-resistant Escherichia coli, enhancing the antibiotics' potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

315.86

C₁₀H₈CuN₂O₂S₂

14915-37-8

Solid

Green to dark green

N12[O-][Cu+2]3([O-]N4C=CC=CC4=[S]3)[S]=C1C=CC=C2

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Mishra A, et al. Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Org Biomol Chem. 2023;21(12):2539-2544. Published 2023 Mar 22.