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Results for "

PIP4K

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (1) LRRK2 (2) Parasite (1) PI4K (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (3) Neurological Disease (3)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136310

PIP4K-IN-a131 1 Publications Verification	Others	Cancer
PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC₅₀s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways .

HY-136311

NCT-504

Others Neurological Disease

NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC₅₀ of 15.8 μM. NCT-504 is potential for the research of Huntington's disease .

NCT-504	Others	Neurological Disease
NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC₅₀ of 15.8 μM. NCT-504 is potential for the research of Huntington's disease .

HY-RS10562

PIP4K2A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PIP4K2A Human Pre-designed siRNA Set A contains three designed siRNAs for PIP4K2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIP4K2A Human Pre-designed siRNA Set A PIP4K2A Human Pre-designed siRNA Set A

HY-RS10563

PIP4K2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIP4K2B Human Pre-designed siRNA Set A contains three designed siRNAs for PIP4K2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIP4K2B Human Pre-designed siRNA Set A PIP4K2B Human Pre-designed siRNA Set A

HY-RS10564

PIP4K2C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIP4K2C Human Pre-designed siRNA Set A contains three designed siRNAs for PIP4K2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIP4K2C Human Pre-designed siRNA Set A PIP4K2C Human Pre-designed siRNA Set A

HY-139868

BAY-091

Others Cancer

BAY-091 is a novel potent and highly selective inhibitor of the kinase PIP4K2A.

BAY-091	Others	Cancer
BAY-091 is a novel potent and highly selective inhibitor of the kinase *PIP4K2A*.

HY-153119

TMX-4153	Ligands for Target Protein for PROTAC	Others
TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous *PIP4K2C* by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a K_D value of 42 nM. TMX-4153 can be used to synthesize PROTAC .

HY-110150

UNC3230 5 Publications Verification	Others	Inflammation/Immunology Cancer
UNC3230 is a potent, selective and ATP-competitive *PIP5K1C* inhibitor with an IC₅₀ of ~41 nM. UNC3230 also inhibits *PIP4K2C* and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects .

HY-106005

MMV390048 2 Publications Verification	Parasite PI4K	Infection
MMV390048 is a representative of a new chemical class of Plasmodium *PI4K* inhibitor (K_d ^app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .

HY-15800A

CZC-25146	LRRK2	Neurological Disease Inflammation/Immunology
CZC-25146 is a potent and orally active LRRK2 inhibitor with IC₅₀ values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 can be used to research Parkinson's disease and liver diseases .

HY-15800

CZC-25146 hydrochloride	LRRK2	Neurological Disease Inflammation/Immunology
CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC₅₀ values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively. CZC-25146 hydrochloride inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2C as well. CZC-25146 hydrochloride prevents mutant LRRK2-induced injury of neurons in vitro. CZC-25146 hydrochloride exhibits relatively favorable pharmacokinetic properties in mice. CZC-25146 hydrochloride can increase normal α-1-antitrypsin (AAT) secretion and reduce inflammatory cytokines. CZC-25146 hydrochloride can be used to research Parkinson's disease and liver diseases .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701750

	PIP4K2C Protein, Human PIP4K2C; Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; PI(5)P 4-kinase type II gamma; PIP4KII-gamma	Human	E. coli
	PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free. The total length of PIP4K2C Protein, Human is 420 a.a., .

HY-P700597

	PIP4K2B Protein, Human (His) PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; phosphatidylinositol 4 phosphate 5 kinase, type II, beta , PIP5K2B; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; PIP5KIIB; PIP5KIIbeta; PIP4KII-beta; PTDINS(4)P-5-kinase; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; PI5P4KB; PIP5K2B	Human	E. coli
	PIP4K2B Protein actively synthesizes phosphatidylinositol 4,5-bisphosphate, preferring GTP over ATP in PI(5)P phosphorylation, with enzymatic activity linked to physiological GTP levels. Its unique GTP-sensing ability critically aids metabolic adaptation. PIP4K2B, part of PIP4Ks, negatively influences insulin signaling via a catalytic-independent mechanism, interacting with PIP5Ks to suppress PIP5K-mediated PtdIns(4,5)P2 synthesis, hindering insulin-dependent conversion to PtdIns(3,4,5)P3. This multifaceted role emphasizes PIP4K2B's significance in modulating key signaling pathways for cellular homeostasis and metabolic responsiveness. PIP4K2B Protein, Human (His) is the recombinant human-derived PIP4K2B protein, expressed by E. coli, with N-10*His labeled tag. The total length of PIP4K2B Protein, Human (His) is 415 a.a., with molecular weight of 53.3 kDa.

HY-P71206

	PIP4K2A Protein, Human (HEK293, His) 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha	Human	HEK293
	The PIP4K2A protein phosphorylates phosphatidylinositol 5-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP4K2A Protein, Human (HEK293, His) is the recombinant human-derived PIP4K2A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PIP4K2A Protein, Human (HEK293, His) is 406 a.a., with molecular weight of 52-58 kDa.


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