PIP4K2C Protein, Human

PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free.

PIP4K2C Protein, a phosphatidylinositol 5-phosphate 4-kinase, exhibits low enzymatic activity and is proposed to function as a GTP sensor, displaying higher GTP-dependent kinase activity compared to ATP-dependent kinase activity. Beyond its catalytic role, PIP4K2C, like other PIP4Ks, plays a significant role in negatively regulating insulin signaling through a catalytic-independent mechanism. This involves the interaction with PIP5Ks, leading to the suppression of PIP5K-mediated phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) synthesis and inhibiting the insulin-dependent conversion to phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). These regulatory actions underscore the intricate involvement of PIP4K2C in cellular processes related to insulin signaling and lipid metabolism.

Human

E. coli

Tag Free

Q8TBX8 (A2-A421)

79837

Full Length of Mature Protein

ASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.