PIP4K2C Protein, Human
PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
PIP4K2C protein is a low-activity phosphatidylinositol 5-phosphate 4-kinase that functions as a GTP sensor, and its GTP-dependent kinase activity is higher than ATP-dependent activity. In addition to its catalytic role, PIP4K2C independently negatively regulates insulin signaling by interacting with PIP5K and inhibits PIP5K-mediated PtdIns(4,5)P2 synthesis. PIP4K2C Protein, Human is the recombinant human-derived PIP4K2C protein, expressed by E. coli , with tag free.
PIP4K2C Protein, a phosphatidylinositol 5-phosphate 4-kinase, exhibits low enzymatic activity and is proposed to function as a GTP sensor, displaying higher GTP-dependent kinase activity compared to ATP-dependent kinase activity. Beyond its catalytic role, PIP4K2C, like other PIP4Ks, plays a significant role in negatively regulating insulin signaling through a catalytic-independent mechanism. This involves the interaction with PIP5Ks, leading to the suppression of PIP5K-mediated phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) synthesis and inhibiting the insulin-dependent conversion to phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). These regulatory actions underscore the intricate involvement of PIP4K2C in cellular processes related to insulin signaling and lipid metabolism.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q8TBX8 (A2-A421)
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Gene ID79837
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Molecular Construction
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N-term
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PIP4K2C (A2-A421)
Accession # Q8TBX8 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
PIP4K2C; PI(5)P 4-Kinase Type II Gamma; Prev. PIP5K2C; FLJ22055; Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma; Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma; Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma; Phosphatidylinosit
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AA Sequence
ASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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