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Cat. No.: HY-136311
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NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease.

For research use only. We do not sell to patients.

NCT-504 Chemical Structure

NCT-504 Chemical Structure

CAS No. : 1222765-97-0

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NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1].

IC50 & Target

IC50: 15.8 μM (PIP4Kγ)[1]

In Vitro

NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate[1].
NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1].
NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration[1].
NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1].
NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs[1].
NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1].
NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1].
NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1].
NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 5 μM, 10 μM
Incubation Time: 2 hours, 6 hours
Result: Induced autophagosome formation.
Molecular Weight









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