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PIP4K-IN-a131 

Cat. No.: HY-136310
Handling Instructions

PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways.

For research use only. We do not sell to patients.

PIP4K-IN-a131 Chemical Structure

PIP4K-IN-a131 Chemical Structure

CAS No. : 2055405-95-1

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Description

PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways[1].

IC50 & Target

IC50: 1.9 µM (PIP4K2A), 0.6 µM (PIP4Ks)[1]

In Vitro

PIP4K-IN-a131 (0-100 μM; 72 hours) is a potent antiproliferative agent with a clear selectivity toward cancer cells killing[1].
PIP4K-IN-a131 eliminates cancer cells via a dual-inhibitory mechanism[1].
PIP4K-IN-a131 causes inhibition of the PI3K/Akt/mTOR pathway only in normal BJ cells, but not in transformed counterparts[1].
Inhibition of PIP4Ks by PIP4K-IN-a131 arrests normal cells at the G1/S phase of the cell cycle by suppressing the PI3K/Akt/mTOR signaling pathway via transcriptional upregulation of PIK3IP1[1].

Cell Proliferation Assay[1]

Cell Line: Normal and transformed BJ cells
Concentration: 0-100 μM (MTT assay)
Incubation Time: 72 hours
Result: Selective killed cancer cells.

RT-PCR[1]

Cell Line: BJ cells
Concentration: 5 µM
Incubation Time: 24 hours
Result: Induced the upregulation of PIK3IP1 mRNA levels.
Molecular Weight

295.34

Formula

C₂₀H₁₃N₃

CAS No.

2055405-95-1

SMILES

N#C/C(C1=CNC2=C1C=CC=C2)=C\C3=CC=CC4=C3C=CN=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PIP4K-IN-a131OthersIP4Klipidkinasescancer-selectivemitoticPI3K/Akt/mTORRas/Raf/MEK/ERKRasInhibitorinhibitorinhibit

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PIP4K-IN-a131
Cat. No.:
HY-136310
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