BAY-091
Based on 1 Customer Validation
BAY-091, a chemical probe, is a potent and highly selective inhibitor of the kinase PIP4K2A.
For research use only. We do not sell to patients.
- Purity: 98.45%
- CAS No.: 2922280-34-8
- Formula: C26H21FN4O2
- Molecular Weight:440.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EBC-1 | IC50 |
30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human EBC-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human EBC-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
| NCI-H460 | IC50 |
>30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human NCI-H460 cells harboring wild type p53 assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human NCI-H460 cells harboring wild type p53 assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
| THP-1 | IC50 |
>30 μM
Compound: 60; BAY-091
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Antiproliferative activity against human THP-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human THP-1 cells harboring p53 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
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[PMID: 34699202] |
BAY-091 (1 μM, 24 h) reduces the production of Hb γ chain in K562 and KU812 cells. BAY-091 reduces the conversion of PtdIns5P into other phosphatidylinositols, increases its bioavailability, thereby affecting the chromatin structure[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2922280-34-8
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Appearance Solid
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Molecular Weight 440.47
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Formula C26H21FN4O2
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Color Light yellow to light brown
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SMILES
CC[C@@H](NC1=C(C#N)C(C2=CC=C(C3=CC=CC(C)=C3F)C=C2)=NC4=CN=CC=C14)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (283.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2703 mL | 11.3515 mL | 22.7030 mL | 56.7576 mL |
| 5 mM | 0.4541 mL | 2.2703 mL | 4.5406 mL | 11.3515 mL | |
| 10 mM | 0.2270 mL | 1.1352 mL | 2.2703 mL | 5.6758 mL | |
| 15 mM | 0.1514 mL | 0.7568 mL | 1.5135 mL | 3.7838 mL | |
| 20 mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.8379 mL | |
| 25 mM | 0.0908 mL | 0.4541 mL | 0.9081 mL | 2.2703 mL | |
| 30 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8919 mL | |
| 40 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4189 mL | |
| 50 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL | |
| 60 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 80 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.7095 mL | |
| 100 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5676 mL |
BAY-091 Related Classifications
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