2. Anti-infection PI3K/Akt/mTOR
  3. Parasite PI4K
  4. MMV390048

MMV390048 

Cat. No.: HY-106005 Purity: 99.17%
COA Handling Instructions

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.

For research use only. We do not sell to patients.

MMV390048 Chemical Structure

MMV390048 Chemical Structure

CAS No. : 1314883-11-8

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 182 In-stock
Solution
10 mM * 1 mL in DMSO USD 182 In-stock
Solid
5 mg USD 165 In-stock
10 mg USD 275 In-stock
25 mg USD 550 In-stock
50 mg USD 880 In-stock
100 mg USD 1375 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

MMV390048 Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

View All Isoforms
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma

View All PI4K Isoform Specific Products:

View All Isoforms
PI4KIIIβ PI4KIIIα PI4K PI4KII

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

IC50 & Target

Plasmodium

 

In Vitro

MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MMV390048 Related Antibodies
Clinical Trial
Molecular Weight

393.38

Appearance

Solid

Formula

C18H14F3N3O2S
CAS No.
SMILES

NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5421 mL 12.7104 mL 25.4207 mL
5 mM 0.5084 mL 2.5421 mL 5.0841 mL
10 mM 0.2542 mL 1.2710 mL 2.5421 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.36 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.17%

COA (248 KB) HNMR (263 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References
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MMV390048 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MMV3900481314883-11-8MMV 390048MMV-390048ParasitePI4KPhosphatidylinositol 4 kinasesPI4 kinasesInhibitorinhibitorinhibit

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