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  3. MMV390048

MMV390048 

Cat. No.: HY-106005
Handling Instructions

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.

For research use only. We do not sell to patients.

MMV390048 Chemical Structure

MMV390048 Chemical Structure

CAS No. : 1314883-11-8

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Description

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

IC50 & Target

Kdapp: 0.3 µM (Plasmodium PI4K inhibitor)[1]

In Vitro

MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.

Molecular Weight

393.38

Formula

C₁₈H₁₄F₃N₃O₂S

CAS No.

1314883-11-8

SMILES

NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MMV390048
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HY-106005
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