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Results for "

S.+pneumoniae

" in MedChemExpress (MCE) Product Catalog:

20

Inhibitors & Agonists

1

Peptides

3

Natural
Products

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136429A
    Ethylhydrocupreine hydrochloride

    Optochin hydrochloride

    		 Bacterial Parasite Infection
    Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine hydrochloride
  • HY-N10495
    Seconeolitsine

    		Antibiotic Bacterial Topoisomerase Infection
    Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics .
    Seconeolitsine
  • HY-136429
    Ethylhydrocupreine

    Optochin

    		 Bacterial Parasite Infection
    Ethylhydrocupreine (Optochin) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine
  • HY-139982
    OX11

    		Bacterial Infection
    OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa, and E. coli bacterial strains .
    OX11
  • HY-N16459
    Albomycin δ1

    		Antibiotic Bacterial Infection
    Albomycin δ1 is a selective bacterial ribosome-targeted antibiotic (MIC: 0.0625 μg/mL against S. pneumoniae). Albomycin δ1 exerts bactericidal activity via covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. Albomycin δ1 is promising for research of S. pneumoniae and S. aureus infections .
    Albomycin δ1
  • HY-N16460
    Albomycin δ2

    		Antibiotic Bacterial Infection
    Albomycin δ2 is a siderophore-antibiotic conjugate targeting bacterial ribosomes (MIC: 0.0625 μg/mL against S. pneumoniae, 0.125 μg/mL against MRSA). Albomycin δ2 is promising for research of Streptococcus pneumoniae and Staphylococcus aureus infections .
    Albomycin δ2
  • HY-113619
    ABT-255 free base

    		Bacterial Infection
    ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis .
    ABT-255 free base
  • HY-156661
    MurF-IN-1

    		E1/E2/E3 Enzyme Infection
    MurF-IN-1 (Compound 7) is a MurF inhibitor with an pIC50 of 5.19 against S. pneumoniae MurF .
    MurF-IN-1
  • HY-P3119
    Desotamide

    Desotamide A

    		 Bacterial Antibiotic Infection
    Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).
    Desotamide
  • HY-105425
    DWC 751

    		Bacterial Antibiotic Infection
    DWC 751 is a cephalosporin antibiotic. DWC 751 exhibits activity against most Gram-positive bacteria, such as methicillin-sensitive Staphylococcus aureus and S. pneumoniae, as well as Gram-negative bacteria including E. coli and E. cloacae. DWC 751 can be used in the research of infectious diseases .
    DWC 751
  • HY-174756
    Human CCL26 mRNA

    		mRNA Inflammation/Immunology
    Human CCL26 mRNA encodes the human C-C motif chemokine ligand 26 (CCL26) protein, a cytokine that displays chemotactic activity for normal peripheral blood eosinophils and basophils. CCL26 also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.
    Human CCL26 mRNA
  • HY-174758
    Human CCL24 mRNA

    		mRNA Inflammation/Immunology
    Human CCL24 mRNA encodes the human C-C motif chemokine ligand 24 (CCL24) protein, a cytokine that displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa.
    Human CCL24 mRNA
  • HY-174227
    Topoisomerase inhibitor 6

    		Topoisomerase Bacterial Infection
    Topoisomerase inhibitor 6 (Compound REDX05931) is a dual irreversible inhibitor of DNA gyrase and topoisomerase IV (MIC=0.06 μg/mL against fluoroquinolone-resistant S. aureus). Topoisomerase inhibitor 6 blocks DNA strand break-reunion, inducing lethal DNA damage. Topoisomerase inhibitor 6 is promising for research of Gram-positive bacterial infections (e.g., S. aureus, S. pneumoniae) .
    Topoisomerase inhibitor 6
  • HY-136429AR
    Ethylhydrocupreine hydrochloride (Standard)

    Optochin hydrochloride (Standard)

    		 Reference Standards Bacterial Parasite Infection
    Ethylhydrocupreine (hydrochloride) (Standard) is the analytical standard of Ethylhydrocupreine (hydrochloride). This product is intended for research and analytical applications. Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist .
    Ethylhydrocupreine hydrochloride (Standard)
  • HY-113619A
    ABT-255 hydrochloride

    		Bacterial Infection
    ABT-255 hydrochloride is an orally active anti-bacterial agent. ABT-255 hydrochloride exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 hydrochloride shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 hydrochloride can be used for the study of pulmonary tuberculosis .
    ABT-255 hydrochloride
  • HY-W587414
    Neospiramycin I

    		Bacterial Antibiotic Infection
    Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I (HY-N7141). Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus, but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations (MIC) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae, with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli, with an inhibitory concentration 50 (IC50) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg .
    Neospiramycin I
  • HY-179038
    PYO12

    		Bacterial Infection
    PYO12 is a 3-phenyl-4-phenoxypyrazole type antibacterial compound. PYO12 exhibits selective activity against Gram-positive bacteria with MIC for S. aureus, B. subtilis, S. pneumoniae, and MRSA of 1, 1, 1, and 4 μg/mL respectively. PYO12 has no activity against Gram-negative bacteria. PYO12 can significantly increase bacterial membrane permeability and significantly upregulate cell wall stress-related genes, possibly by binding to the C55-PP part of lipid II. PYO12 shows a concentration-dependent bactericidal effect, has low toxicity to mammalian cells, and does not cause hemolysis. PYO12 can be used to develop new antibiotics targeting bacterial cell wall synthesis .
    PYO12
  • HY-W653770
    Desmycosin

    		Antibiotic Infection
    Desmycosin is a macrolide antibiotic. Desmycosin exhibits biological activity against H. influenzae, S.aureus, S. pneumoniae, and S. pyogenes with MIC values of 4, 1, <0.125, and <0.125 µg/ml, respectively. Desmycosin is an acidic degradation product of tylosin .
    Desmycosin
  • HY-182022
    ZLWH-67

    		Bacterial Reactive Oxygen Species (ROS) Drug Derivative DNA/RNA Synthesis Infection
    ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models .
    ZLWH-67
  • HY-179637
    RNAP-σ interaction-IN-4

    		Bacterial DNA/RNA Synthesis Infection
    RNAP-σ interaction-IN-4 (Compound 3a) is an inhibitor of the RNA polymerase-sigma factor interaction (RNAP-σ) with MIC values against S. pneumoniae and S. aureus of 1 μg/mL and 2 μg/mL, respectively. RNAP-σ interaction-IN-4 exhibits strong bactericidal properties by interfering with the interaction of β′CH−σ and disrupting the transcription of bacteria. RNAP-IN-2 shows significant efficacy in sepsis models. RNAP-σ interaction-IN-4 can be used to study Gram-positive bacterial infections caused by multi-drug resistant strains .
    RNAP-σ interaction-IN-4

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