Desotamide
Based on 1 Customer Validation
Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).
For research use only. We do not sell to patients.
- Purity : 98.23%
- CAS No.: 194660-14-5
- Formula: C35H52N8O7
- Molecular Weight:696.84
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
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[PMID: 25072108] |
| MCF7 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
|
[PMID: 25072108] |
| NCI-H460 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human NCI-H460 after 72 hrs by SRB assay
Cytotoxicity against human NCI-H460 after 72 hrs by SRB assay
|
[PMID: 25072108] |
| SF-268 | IC50 |
>100 μM
Compound: 1
|
Cytotoxicity against human SF268 cells after 72 hrs by SRB assay
Cytotoxicity against human SF268 cells after 72 hrs by SRB assay
|
[PMID: 25072108] |
Chemical Information
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CAS No. 194660-14-5
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Appearance Solid
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Molecular Weight 696.84
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Formula C35H52N8O7
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Synonyms
Desotamide A
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Sequence
cyclo(Asn-Gly-Trp-Leu-DLeu-L-allo-Ile)
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Sequence Shortening
cyclo(NGWL-DLeu-L-allo-Ile)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (71.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4350 mL | 7.1752 mL | 14.3505 mL | 35.8762 mL |
| 5 mM | 0.2870 mL | 1.4350 mL | 2.8701 mL | 7.1752 mL | |
| 10 mM | 0.1435 mL | 0.7175 mL | 1.4350 mL | 3.5876 mL | |
| 15 mM | 0.0957 mL | 0.4783 mL | 0.9567 mL | 2.3917 mL | |
| 20 mM | 0.0718 mL | 0.3588 mL | 0.7175 mL | 1.7938 mL | |
| 25 mM | 0.0574 mL | 0.2870 mL | 0.5740 mL | 1.4350 mL | |
| 30 mM | 0.0478 mL | 0.2392 mL | 0.4783 mL | 1.1959 mL | |
| 40 mM | 0.0359 mL | 0.1794 mL | 0.3588 mL | 0.8969 mL | |
| 50 mM | 0.0287 mL | 0.1435 mL | 0.2870 mL | 0.7175 mL | |
| 60 mM | 0.0239 mL | 0.1196 mL | 0.2392 mL | 0.5979 mL |
Desotamide Related Classifications
HY-P3119 Related Classifications
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