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Cat. No.: HY-P3119

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Desotamide

(Synonyms: Desotamide A)

Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs=16, 12.5, and 32 μg/mL, respectively).

For research use only. We do not sell to patients.

CAS No.: 194660-14-5
Formula: C₃₅H₅₂N₈O₇
Molecular Weight:696.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Desotamide Chemical Structure

CAS No.: 194660-14-5

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Sample (0.1mg)

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(In Japan)

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>100 μM Compound: 1	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 25072108]
MCF7	IC₅₀	>100 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 25072108]
NCI-H460	IC₅₀	>100 μM Compound: 1	Cytotoxicity against human NCI-H460 after 72 hrs by SRB assay Cytotoxicity against human NCI-H460 after 72 hrs by SRB assay	[PMID: 25072108]
SF-268	IC₅₀	>100 μM Compound: 1	Cytotoxicity against human SF268 cells after 72 hrs by SRB assay Cytotoxicity against human SF268 cells after 72 hrs by SRB assay	[PMID: 25072108]

Chemical Information

CAS No. 194660-14-5
Molecular Weight 696.84
Formula C₃₅H₅₂N₈O₇
Synonyms

Desotamide A
Sequence

cyclo(Asn-Gly-Trp-Leu-Leu-Ile)
Sequence Shortening

cyclo(NGWLLI)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miao, et al. Inhibition of bacterial RNA polymerases. Peptide metabolites from the cultures of Streptomyces sp. J. Nat. Prod. 60(8), 858-861 (1997).

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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