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  2. Bacterial
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  3. Ethylhydrocupreine hydrochloride

Ethylhydrocupreine hydrochloride (Synonyms: Optochin hydrochloride)

Cat. No.: HY-136429A
Handling Instructions

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist.

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Ethylhydrocupreine hydrochloride Chemical Structure

Ethylhydrocupreine hydrochloride Chemical Structure

CAS No. : 3413-58-9

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Description

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4].

IC50 & Target

S. pneumoniae[1]
IC50: 25.75 nM (Plasmodium falciparum)[3]
ggTas2r1, ggTas2r2 and ggTas2r7[4]

In Vitro

The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied[2].

In Vivo

The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1].

Molecular Weight

376.92

Formula

C₂₁H₂₉ClN₂O₂

CAS No.

3413-58-9

SMILES

O[[email protected]@H]([[email protected]@](C[[email protected]@H]1CC2)([H])[[email protected]@]2C[[email protected]@H]1CC)C3=CC=NC(C=C4)=C3C=C4OCC.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EthylhydrocupreineOptochinBacterialParasiteAntimicrobialbactericidalbittertasteggTas2r1ggTas2r2ggTas2r7antimalarialS. pneumoniaeInhibitorinhibitorinhibit

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Ethylhydrocupreine hydrochloride
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