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  2. Bacterial
    Parasite
  3. Ethylhydrocupreine hydrochloride

Ethylhydrocupreine hydrochloride (Synonyms: Optochin hydrochloride)

Cat. No.: HY-136429A Purity: 99.83%
Handling Instructions

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist.

For research use only. We do not sell to patients.

Ethylhydrocupreine hydrochloride Chemical Structure

Ethylhydrocupreine hydrochloride Chemical Structure

CAS No. : 3413-58-9

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25 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 130 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ethylhydrocupreine hydrochloride:

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Description

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4].

IC50 & Target

S. pneumoniae[1]
IC50: 25.75 nM (Plasmodium falciparum)[3]
ggTas2r1, ggTas2r2 and ggTas2r7[4]

In Vitro

The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains (S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.92

Formula

C₂₁H₂₉ClN₂O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (331.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6531 mL 13.2654 mL 26.5308 mL
5 mM 0.5306 mL 2.6531 mL 5.3062 mL
10 mM 0.2653 mL 1.3265 mL 2.6531 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Ethylhydrocupreine hydrochloride
Cat. No.:
HY-136429A
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