3413-58-9
Chemical Structure
Ethylhydrocupreine hydrochloride
Synonym(s): Optochin hydrochloride
- CAS No.: 3413-58-9
- Formula:C21H29ClN2O2
- Molecular Weight:376.92
IUPAC Name: (R)-(6-ethoxyquinolin-4-yl)((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)methanol hydrochloride
InChIKey: QNRATNLHPGXHMA-XZHTYLCXSA-N
SMILES: O[C@@H]([C@@](C[C@@H]1CC2)([H])[N@@]2C[C@@H]1CC)C3=CC=NC(C=C4)=C3C=C4OCC.Cl
Biological Activity: Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist[1][2][3][4].
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Ethylhydrocupreine hydrochloride | 99.38% | Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist. | ||||||||||||||||||||
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Ethylhydrocupreine hydrochloride (Standard) | ≥98% | Ethylhydrocupreine (hydrochloride) (Standard) is the analytical standard of Ethylhydrocupreine (hydrochloride). This product is intended for research and analytical applications. Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a quinine derivate with antimicrobial activity against S. pneumoniae. Ethylhydrocupreine hydrochloride also possesses antimalarial activity against Plasmodium falciparum, with an IC50 of 25.75 nM. Ethylhydrocupreine hydrochloride is a Gallus gallus taste 2 receptors (ggTas2r1, ggTas2r2 and ggTas2r7) agonist. | ||||||||||||||||||||
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Similarity Score 0.98
HY-136429Ethylhydrocupreine -
Similarity Score 0.91
HY-W009065Hydroquinidine hydrochloride -
Similarity Score 0.89
HY-42034Hydroquinine -
Similarity Score 0.89
HY-B0997RHydroquinidine (Standard) -
Similarity Score 0.83
HY-W0724596'-Hydroxydihydrocinchonidine -
Similarity Score 0.78
HY-110082Quinine (hydrochloride) -
Similarity Score 0.78
HY-W115674Quinidine hydrochloride -
Similarity Score 0.78
HY-B1302Quinidine hydrochloride monohydrate -
Similarity Score 0.78
HY-D0143ARQuinine dihydrochloride (Standard) -
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References
- [1]. J A Kolmer, et al. CHEMOTHERAPEUTIC STUDIES WITH ETHYLHYDROCUPREINE HYDROCHLORIDE IN EXPERIMENTAL PNEUMOCOCCUS PLEURITIS. J Exp Med. 1921 May 31;33(6):693-711. [Content Brief]
- [2]. Paulo R Cortes, et al. Subinhibitory Concentrations of Penicillin Increase the Mutation Rate to Optochin Resistance in Streptococcus Pneumoniae. J Antimicrob Chemother. 2008 Nov;62(5):973-7. [Content Brief]
- [3]. Nassira Mahmoudi, et al. Identification of New Antimalarial Drugs by Linear Discriminant Analysis and Topological Virtual Screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97. [Content Brief]
- [4]. Antonella Di Pizio, et al. Molecular Features Underlying Selectivity in Chicken Bitter Taste Receptors. Front Mol Biosci. 2018 Jan 31;5:6. [Content Brief]
