Art. -Nr.: HY-110082

Quinine (hydrochloride)

Name: Quinine (hydrochloride)
Brand: MedChemExpress
SKU: HY-110082
Price: 31.00 USD
Availability: InStock
Rating: 5 (7 reviews)

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Quinine hydrochloride is an alkaloid extracted from cinchona bark and exhibits oral activity, acting as a potassium channel inhibitor. Quinine hydrochloride modulates the tolerance of red blood cells and presents dose-dependent toxicity and embryonic effects. Quinine hydrochloride is a typical hemolysin that directly lyses red blood cells, with cellular components of red blood cell membranes as its action targets. Quinine hydrochloride disrupts red blood cell membranes and induces hemolysis at high concentrations, while merely weakening the anti-hemolytic capacity of red blood cells at low concentrations. Quinine hydrochloride continuously reduces red blood cell tolerance after in vivo administration, and high doses can also alter blood cell counts. Quinine hydrochloride can be applied to researches related to red blood cell hemolysis, cancer and malaria.

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Reinheit: 99.83%
CAS. Nr.: 130-89-2
Formel: C₂₀H₂₅ClN₂O₂
Molecular Weight:360.88

Speicherung:

RT, stored under nitrogen.

In solvent -80°C, 1 year , -20°C, 6 months

Quinine (hydrochloride) Chemical Structure

CAS. Nr.: 130-89-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Quinine hydrochloride acts as a simple hemolysin on rabbit erythrocytes; pretreatment of rabbit erythrocytes reduces their resistance to the lytic effects of saponin and sodium taurocholate in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Quinine hydrochloride (25-250 mg/kg per day; oral administration; daily dosing for 4 consecutive weeks) reduces food intake and body weight in rats, alters spleen weight in male rats, and decreases kidney and adrenal gland weights in female rats^[3].
Quinine hydrochloride (administered orally daily at doses of 1-200 mg/kg for 13 consecutive weeks) causes dose-dependent decreases in body weight and food intake, as well as reversible biochemical changes^[3].
Quinine hydrochloride (60-120 mg/kg per day; p.o.; daily administration; for 13 consecutive weeks) causes reversible inhibition of body weight gain, reduced food intake, and transient increases in kidney weight in male rats at doses ≥85 mg/kg per day^[3].
Quinine hydrochloride (85-200 mg/kg per day; p.o.; daily administration; for 13 consecutive weeks) does not induce ototoxic effects or hearing impairment^[3].
Quinine hydrochloride (50-200 mg/kg per day; p.o.; daily administration; gestational days 6-15) is orally administered to mated Sprague-Dawley rats on gestational days 6-15. Maternal toxicity occurs at doses ≥100 mg/kg, while mild fetal effects (decreased body weight, increased incidence of malformations) are observed at a dose of 200 mg/kg^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male and female)^[3]
Dosage:

25 mg/kg per day; 100 mg/kg per day; 200 mg/kg per day; 250 mg/kg per day
Administration:

p.o.; daily; 4 weeks
Result:

Decreased food intake and body weight at 100, 200 and 250 mg/kg daily.
Slightly impaired food utilization at the end of the study.
Suppressed weight gain in females at 25 mg/kg daily.
Elevated spleen weight in all treated male rats.
Lowered kidney and adrenal weights in all treated female rats.

Animal Model:

Sprague-Dawley (male and female)^[3]
Dosage:

1 mg/kg per day; 10 mg/kg per day; 40 mg/kg per day; 100 mg/kg per day; 200 mg/kg per day
Administration:

p.o.; daily; 13 weeks
Result:

Retarded body weight gain at 100 and 200 mg/kg daily.
Decreased food intake and utilization at 200 mg/kg daily.
Accelerated weight gain in the 200 mg/kg group during recovery.
Raised plasma urea across genders at 100 and 200 mg/kg daily.
Elevated serum inorganic phosphorus in females at 40, 100 and 200 mg/kg daily.
Lowered total protein in females at 100 and 200 mg/kg daily.
Reversed all biochemical alterations in the recovery period.
Aggravated periportal glycogen depletion in females at 100 and 200 mg/kg daily.
Produced no changes in organ weight, vision or hearing function.

Animal Model:

Sprague-Dawley (male and female)^[3]
Dosage:

60 mg/kg per day; 85 mg/kg per day; 120 mg/kg per day
Administration:

p.o.; daily; 13 weeks
Result:

Recorded no drug-related deaths.
Induced mild alopecia since week 3 at 120 mg/kg daily.
Retarded weight gain and food intake at 85/120 mg/kg daily, reversible during recovery.
Elevated phosphorus in females at 120 mg/kg daily, with partial persistence.
Increased kidney weight in males at 85/120 mg/kg daily, which recovered later.
Caused no abnormalities in blood, urine, ophthalmic and histological examinations.

Animal Model:

Sprague-Dawley (time-mated female)^[3]
Dosage:

50 mg/kg per day; 100 mg/kg per day; 200 mg/kg per day
Administration:

p.o.; daily; gestation days 6-15
Result:

Induced salivation, partial alopecia, excessive water intake and mild growth retardation in maternal rats at 100 and 200 mg/kg daily.
Exerted no impacts on litter size, embryo survival and foetal malformation rate across all doses.
Remarkably lowered average foetal weight at the 200 mg/kg daily dose.
Elevated the rates of visceral anomalies, skeletal anomalies and sternebrae variations in foetuses at 200 mg/kg daily.

Chemical Information

CAS. Nr. 130-89-2
Appearance Solid
Molecular Weight 360.88
Formel C₂₀H₂₅ClN₂O₂
Color White to off-white
SMILES

O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.Cl
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

RT, stored under nitrogen

In solvent	-80°C	1 year
	-20°C	6 months

Publications (7)

All In Vivo Efficacy StudyCell Imaging/StainingBio/Physico-chemical AssayCell Proliferation/Viability Assay

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Journal Impact Factor

Neurosci Bull

A Novel Functional Method of Protector Screening for Zebrafish Lateral Line Hair Cells via the Acoustic Escape Response. [Abstract]

2025 May 6. PMID: 40329138

Quinine (hydrochloride) purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 May 6. [Abstract]

Quinine (qui; 10 μM; 5 min) decreased the travel distance upon sound stimulation in zebrafish.

Quinine (hydrochloride) purchased from MedChemExpress. Usage Cited in: Neurosci Bull. 2025 May 6. [Abstract]

Quinine (qui; 10 μM; 5 min) remained unchanged in the number of HCs in zebrafish.
Cell Mol Life Sci

The contrasting effects of two antimalarial drugs on insulin secretion. [Abstract]

2025 Nov 25;82(1):419. PMID: 41288707

Quinine (hydrochloride) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Nov 25;82(1):419. [Abstract]

Quinine (0-320 μM) showed no cytotoxicity for Primary pancreatic β cells.
J Mol Cell Biol

Low-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion. [Abstract]

2025 May 22;16(11):mjae051. PMID: 39848918

Quinine (hydrochloride) purchased from MedChemExpress. Usage Cited in: J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]

Quinine (0-320 μM; 24 h) showed cytotoxicity in primary pancreatic β cells and HEK293T cells.

Quinine (hydrochloride) purchased from MedChemExpress. Usage Cited in: J Mol Cell Biol. 2025 May 22;16(11):mjae051. [Abstract]

Quinine (0-40 μM) potentiated high glucose (25 mM)-evoked insulin secretion in a dose-dependent manner at 5–100 μM. However, under low-glucose (2 mM) conditions, quinine induced insulin secretion only at concentrations of 50–100 μM; without the addition of glucose, 5 μM quinine alone was not sufficient to stimulate insulin secretion.
ACS Omega

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]

2024 Feb 28;9(10):11870-11882. PMID: 38496939
Mol Med Rep

Therapeutic effects of quinine in a mouse model of atopic dermatitis. [Abstract]

2021 May;23(5):313. PMID: 34240224
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Norwegian University of Science and Technology

2019 Sep.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (277.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7710 mL

13.8550 mL

27.7100 mL

5 mM

0.5542 mL

2.7710 mL

5.5420 mL

10 mM

0.2771 mL

1.3855 mL

2.7710 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.93 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (6.93 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ponder E, et al. Effect of Quinine Hydrochloride on Resistance of Rabbit Red Cells. [Journal Name]. 1936 Mar;34(2).

[2]. Muhtadi FJ, et al. Quinine Hydrochloride. Anal Profiles Drug Subst. 1983;12:547-621.

[3]. Colley JC, et al. Toxicity studies with quinine hydrochloride. Toxicology. 1989 Feb;54(2):219-226.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7710 mL	13.8550 mL	27.7100 mL	69.2751 mL
	5 mM	0.5542 mL	2.7710 mL	5.5420 mL	13.8550 mL
	10 mM	0.2771 mL	1.3855 mL	2.7710 mL	6.9275 mL
	15 mM	0.1847 mL	0.9237 mL	1.8473 mL	4.6183 mL
	20 mM	0.1386 mL	0.6928 mL	1.3855 mL	3.4638 mL
	25 mM	0.1108 mL	0.5542 mL	1.1084 mL	2.7710 mL
	30 mM	0.0924 mL	0.4618 mL	0.9237 mL	2.3092 mL
	40 mM	0.0693 mL	0.3464 mL	0.6928 mL	1.7319 mL
	50 mM	0.0554 mL	0.2771 mL	0.5542 mL	1.3855 mL
	60 mM	0.0462 mL	0.2309 mL	0.4618 mL	1.1546 mL
	80 mM	0.0346 mL	0.1732 mL	0.3464 mL	0.8659 mL
	100 mM	0.0277 mL	0.1386 mL	0.2771 mL	0.6928 mL

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Keywords

Quinine (hydrochloride)

7 Cited Publications

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Quinine (hydrochloride)

Publications Citing Use of MedChemExpress (MCE) Quinine (hydrochloride)

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