ABT-255 free base
ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 186293-38-9
- Formula: C21H24FN3O3
- Molecular Weight:385.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ABT-255 (0.016-0.5 μg/mL) free base shows MIC values of 0.016 μg/mL against ATCC 35801, 0.031 μg/mL against ATCC 25618, and 0.031 μg/mL against both 35837b (Ethambutol (HY-B0535)-resistant) and 35838c (Rifampin (HY-B0272)-resistant)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4- to 6-week-old female CF-1 mice were intraperitoneally injected with overnight cultures of Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli JUHL, with the inoculum adjusted to approximately 100 times the 50% lethal dose[1]
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Dosage:3.13, 6.25, 12.5, 25 mg/kg
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Administration:p.o. once daily for 4 weeks
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Result:Reduced Staphylococcus aureus NTCC 10649, Streptococcus pneumoniae 6303, or Escherichia coli in mice JUHL.
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Animal Model:4- to 6-week-old female CF-1 mice were intravenously injected via the caudal tail vein with approximately 107 viable M. tuberculosis cells suspended in 0.2 mL of modified 7H10 broth[1]
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Dosage:6.25, 12.5, 25 mg/kg
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Administration:p.o. once daily for 4 weeks
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Result:Produced a dose-responsive 0- to 5.5-log reduction in M. tuberculosis (ATCC 35801) counts in lung tissue.
Produced a dose-related 1- to 3-log reduction in viable Ethambutol (HY-B0535)-resistant M. tuberculosis (ATCC 35837) counts in lung tissue.
Produced a dose-responsive 1- to 2.5-log reduction in viable Rifampin (HY-B0272)-resistant Mycobacterium tuberculosis (ATCC 35838) counts in lung tissue.
Chemical Information
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CAS No. 186293-38-9
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Molecular Weight 385.43
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Formula C21H24FN3O3
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SMILES
O=C(C1=CC(C2CC2)=C3C(C)=C(N(C4)C[C@]5([H])[C@@]4([H])CCCN5)C(F)=CN3C1=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ABT-255 free base Related Classifications
HY-113619 Related Classifications
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