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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Ser/Thr Kinase
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Ser/Thr Kinase" in MCE Product Catalog:
9
9 Publications Verification
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Research Areas:
AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .
6
6 Cited Publications
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VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders .
3
3 Cited Publications
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2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
1
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Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non–small cell lung cancer, ovarian, and squamous cell cancers .
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NR162 is a selective CASK (Ca 2+/calmodulin-dependent Ser/Thr kinase) inhibitor with an IC50 of 80 nM and a Kd of 22 nM. NR162 shows about 50-fold selectivity for CASK than TYRO3. NR162 targets the unique GFG motif of CASK and has excellent shape complementarity to the CASK ATP binding pocket. NR162 can be used for the research of neurological diseases .
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Protein serine/threonine kinase (Ser/Thr protein kinase) is a signal transduction molecule. Protein serine/threonine kinase phosphorylates specific residues on target substrates, regulates phosphorylation-dependent signal cascades, modulates cellular processes of mycobacteria, blocks phagosome-lysosome fusion, promotes meiotic maturation of Xenopus laevis (African clawed frog) oocytes, rescues the phenotype of Saccharomyces cerevisiae (budding yeast) CDC5 mutants, and exhibits cell cycle phase-specific kinase activity. Protein serine/threonine kinase maintains a tightly regulated cell cycle expression pattern, and sustains the growth and survival of mycobacteria. Protein serine/threonine kinase can be used in studies related to tuberculosis .
Cat. No.: HY-122735
CAS No.: 690216-38-7
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Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly .
Cat. No.: HY-171294
CAS No.: 928316-79-4
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Protein kinase inhibitor 16 exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase .
Cat. No.: HY-171293
CAS No.: 928317-20-8
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Protein kinase inhibitor 15 (Compound A.35.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase .
Cat. No.: HY-171276
CAS No.: 928316-71-6
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Anti-neuroinflammation agent 3 (Compound A.10.3) exhibits inhibitory activity against a variety of Ser/Thr kinase or receptor or non-receptor tyrosine kinase .
Cat. No.: HY-P3766
CAS No.: 159939-84-1
Cat. No.: HY-123702
CAS No.: 660817-08-3
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CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .
Cat. No.: HY-187907
CAS No.: 3038330-83-2
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Surbinsertib is an orally active Ser/Thr kinase inhibitor. Surbinsertib is applicable for cancer research .
Cat. No.: HY-102081R
CAS No.: 833481-73-5
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2OH-BNPP1 (Standard) is the analytical standard of 2OH-BNPP1 (HY-102081). This product is intended for research and analytical applications. 2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.
Cat. No.: HY-11010A
CAS No.: 345987-16-8
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AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .
Cat. No.: HY-P705605
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K9; MEKK9; Prev. MLK1; Mitogen-Activated Protein Kinase Kinase Kinase; PRKE1; Mixed Lineage Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase 9; Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705995
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAP3K9; MEKK9; Prev. MLK1; Mitogen-Activated Protein Kinase Kinase Kinase; PRKE1; Mixed Lineage Kinase 1; Mitogen-Activated Protein Kinase Kinase Kinase 9; Mixed Lineage Kinase 1 (Tyr And Ser/Thr Specificity)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-11010R
CAS No.: 345987-15-7
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Research Areas:
AS601245 (Standard) is the analytical standard of AS601245 (HY-11010). This product is intended for research and analytical applications. AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein Kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein Kinases. Neuroprotective properties .
Cat. No.: HY-P76098
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STK40; Serine/Threonine-Protein Kinase 40; Serine/Threonine Kinase 40; Sugen Kinase 495; SgK495; MGC4796; SHIK; Ser/Thr-Like Kinase; SINK-Homologous Serine/Threonine-Protein Kinase; SGK495; SINK-Homologous Serine/Threonine Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702949
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: STK38; Nuclear Dbf2-Related Kinase 1; Serine/Threonine Kinase 38; NDR1 Protein Kinase; NDR1; Ndr Ser/Thr Kinase-Like Protein; NDR; Nuclear Dbf2-Related 1; Serine/Threonine-Protein Kinase 38
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
