Search Result

Results for "

Ser/Thr Kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ser/Thr Kinase (6) Ser/Thr Protease (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) c-Myc (1) CDK (1) JNK (2) PKC (1) Polo-like Kinase (PLK) (2) Reference Standards (1) VRK (1)
By Research Areas:	Cancer (9) Infection (2) Inflammation/Immunology (5) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Peptides

Antibodies

Targets Recommended: Ser/Thr Kinase Ser/Thr Protease Thyroid Hormone Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126542

VRK-IN-1 5 Publications Verification	VRK	Neurological Disease
VRK-IN-1 is a potent and selective inhibitor of *vaccinia-related kinases* 1 (VRK1), with an IC₅₀** of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders .

HY-147298

Plogosertib 1 Publications Verification CYC140	Polo-like Kinase (PLK)	Cancer
Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC₅₀: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non–small cell lung cancer, ovarian, and squamous cell cancers .

HY-11010

AS601245 Maximum Cited Publications 9 Publications Verification	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-115719

NR162	Ser/Thr Kinase	Neurological Disease
NR162 is a selective CASK (Ca ²⁺/calmodulin-dependent Ser/Thr kinase) inhibitor with an IC₅₀ of 80 nM and a Kd of 22 nM. NR162 shows about 50-fold selectivity for CASK than TYRO3. NR162 targets the unique GFG motif of CASK and has excellent shape complementarity to the CASK ATP binding pocket. NR162 can be used for the research of neurological diseases .

HY-102081

2OH-BNPP1 3 Publications Verification	Ser/Thr Protease	Cancer
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.

HY-P2948

Protein serine/threonine kinase Ser/Thr protein Kinase	Biochemical Assay Reagents	Infection
Protein serine/threonine kinase is a type of serine/threonine protein kinase. Protein serine/threonine kinases are pleiotropic signaling proteins that can phosphorylate various substrates, thereby initiating branched signaling pathways. Mycobacteria protein serine/threonine kinase plays a crucial role in signal transduction pathways, ultimately determining the growth and metabolic adaptability of mycobacteria .

HY-122735

Inh2-B1	Ser/Thr Kinase Bacterial	Infection
Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly .

HY-171294

*Protein kinase* inhibitor 16**	Ser/Thr Kinase	Inflammation/Immunology Cancer
Protein kinase inhibitor 16 exhibits inhibitory activity against a variety of **Ser/Thr kinase** or receptor or non-receptor tyrosine kinase .

HY-171293

*Protein kinase* inhibitor 15**	Ser/Thr Kinase	Inflammation/Immunology Cancer
Protein kinase inhibitor 15 (Compound A.35.3) exhibits inhibitory activity against a variety of **Ser/Thr kinase** or receptor or non-receptor tyrosine kinase .

HY-171276

Anti-neuroinflammation agent 3	Ser/Thr Kinase	Inflammation/Immunology
Anti-neuroinflammation agent 3 (Compound A.10.3) exhibits inhibitory activity against a variety of **Ser/Thr kinase** or receptor or non-receptor tyrosine kinase .

HY-P3766

*Protein kinase* C (alpha) peptide TFA**	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

HY-123702

CAP-53194	Polo-like Kinase (PLK)	Cancer
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .

HY-102081R

2OH-BNPP1 (Standard)	Others Reference Standards	Cancer
2OH-BNPP1 (Standard) is the analytical standard of 2OH-BNPP1 (HY-102081). This product is intended for research and analytical applications. 2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.

HY-11010A

AS601245 TFA	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-180355

SY-5102	CDK Ser/Thr Kinase c-Myc Apoptosis	Cancer
SY-5102 is a potent, selective and orally active cyclin-dependent kinase (CDK7) inhibitor with a K_d of 0.03 nM. SY-5102 shows anti-proliferative activity against HCC70 cells with an EC₅₀ of 9 nM. SY-5102 can inhibit CDK7-mediated CAK function (downregulate CDK2 Thr160 phosphorylation) and TFIIH transcription function (downregulate RNA polymerase II Ser5 phosphorylation). SY-5102 can induce G2/M cell cycle arrest, downregulate the expression of the oncogene c-Myc, and ultimately trigger cancer cell apoptosis. SY-5102 can be used for the research of triple-negative breast cancer (TNBC) .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library	175 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc. Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action. MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Phosphatase Inhibitor Library

175 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 175 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P3766

*Protein kinase* C (alpha) peptide TFA**	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (4) Mouse (5)
Application:	IHC-P (1) ICC/IF (2) IP (4) WB (5) FC (2) ELISA (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (3)
Modification:	Phosphorylated (2) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82359

	MARK2 Antibody (YA2104) ELKL motif Kinase 1 antibody; ELKL motif Kinase antibody; EMK-1 antibody; EMK1 antibody; MAP/microtubule affinity regulating Kinase 2 antibody; MAP/microtubule affinity-regulating Kinase 2 antibody; Mark2 antibody; MARK2_HUMAN antibody; MGC99619 antibody; PAR 1 antibody; Par 1b antibody; PAR1 homolog antibody; Par1b antibody; Ser/Thr protein Kinase PAR 1B antibody; Serine/Threonine protein Kinase EMK antibody; Serine/Threonine protein Kinase MARK2 antibody; Serine/Threonine-protein Kinase MARK2 antibody;	WB, FC	Human, Mouse, Rat
	MARK2 Antibody (YA2104) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MARK2.

HY-P80849

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90 (Thr359/Ser363).

HY-P86403

	Phospho-RSK1 p90(Thr359/Ser363) Antibody (YA6095) (YA6095) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-RSK1 p90(Thr359/Ser363) Antibody (YA6095) (YA6095) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90(Thr359/Ser363).

HY-P80849A

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157)(PBS only) RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody (YA157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK1 p90 (Thr359/Ser363).

HY-P82405

	MARK3 Antibody (YA2150) C-TAK1 antibody; Cdc25C associated protein Kinase 1 antibody; Cdc25C-associated protein Kinase 1 antibody; cTAK1 antibody; ELKL motif Kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating Kinase 3 antibody; MAP/microtubule affinity-regulating Kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; Par 1a antibody; PAR1A antibody; Protein Kinase STK10 antibody; Ser/Thr protein Kinase PAR-1 antibody; Serine Threonine protein Kinase p78 antibody; Serine/Threonine-protein Kinase p78 antibody; SerThr protein Kinase PAR 1 antibody;	WB, ICC/IF, IP, FC	Mouse, Human
	MARK3 Antibody (YA2150) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MARK3.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.