VRK
Vaccinia-Related Kinases
VRKs has three members: VRK1, VRK2, VRK3.
VRKs are implicated in a number of cellular processes and linked to a variety of tumors.
References:
- [1]. Cou?ago RM, et al. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep. 2017 Aug 8;7(1):7501. [Content Brief]
- [2]. Nichols RJ, et al. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004 Feb 27;279(9):7934-46. [Content Brief]
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VRK Related Products (3)
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VRK-IN-1
0 ImagesVRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
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VRK1/CK1-IN-1
0 ImagesVRK1/CK1-IN-1 (compound 36) is a dual VRK1 and CK1 family inhibitor, with a Ki of 37.9 nM against human VRK1, 8.3 nM against human CK1δ, and 7.8 nM against human CK1ε. VRK1/CK1-IN-1 exhibits extremely low activity against VRK2. VRK1/CK1-IN-1 can be used in studies related to p53-deficient tumors.
