VRK-IN-1
Based on 6 publication(s) in Google Scholar
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 2378855-09-3
- Formula: C18H11F4NO2
- Molecular Weight:349.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Heterocyclic Compound Library
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Bioactive Compound Library Max
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Bioactive Compound Library
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Protein Kinase Compound Library
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Publications Citing Use of MedChemExpress (MCE) VRK-IN-1
More
Biological Activity
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VRK1 150 nM (IC50) |
Chemical Information
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CAS No. 2378855-09-3
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Appearance Solid
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Molecular Weight 349.28
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Formula C18H11F4NO2
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Color White to off-white
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SMILES
FC1=C(O)C(F)=CC(C2=C(C)N=CC(C3=CC(F)=C(O)C(F)=C3)=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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EMBO J
2024 Oct;43(20):4752-4785. PMID: 39256562 -
Int J Mol Sci
VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1. [Abstract]2023 Mar 3;24(5):4912. PMID: 36902348 -
Exp Cell Res
Inactivation of VRK1 sensitizes ovarian cancer to PARP inhibition through regulating DNA-PK stability. [Abstract]2024 Apr 16;438(1):114036. PMID: 38614421 -
Epigenetics Chromatin
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase. [Abstract]2023 May 13;16(1):18. PMID: 37179361 -
Mol Biol Rep
2024 Mar 27;51(1):453. PMID: 38536553 -
Solvent & Solubility
DMSO : 100 mg/mL (286.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8630 mL | 14.3152 mL | 28.6303 mL | 71.5758 mL |
| 5 mM | 0.5726 mL | 2.8630 mL | 5.7261 mL | 14.3152 mL | |
| 10 mM | 0.2863 mL | 1.4315 mL | 2.8630 mL | 7.1576 mL | |
| 15 mM | 0.1909 mL | 0.9543 mL | 1.9087 mL | 4.7717 mL | |
| 20 mM | 0.1432 mL | 0.7158 mL | 1.4315 mL | 3.5788 mL | |
| 25 mM | 0.1145 mL | 0.5726 mL | 1.1452 mL | 2.8630 mL | |
| 30 mM | 0.0954 mL | 0.4772 mL | 0.9543 mL | 2.3859 mL | |
| 40 mM | 0.0716 mL | 0.3579 mL | 0.7158 mL | 1.7894 mL | |
| 50 mM | 0.0573 mL | 0.2863 mL | 0.5726 mL | 1.4315 mL | |
| 60 mM | 0.0477 mL | 0.2386 mL | 0.4772 mL | 1.1929 mL | |
| 80 mM | 0.0358 mL | 0.1789 mL | 0.3579 mL | 0.8947 mL | |
| 100 mM | 0.0286 mL | 0.1432 mL | 0.2863 mL | 0.7158 mL |
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