Protein serine/threonine kinase
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Protein serine/threonine kinase (Ser/Thr protein kinase) is a signal transduction molecule. Protein serine/threonine kinase phosphorylates specific residues on target substrates, regulates phosphorylation-dependent signal cascades, modulates cellular processes of mycobacteria, blocks phagosome-lysosome fusion, promotes meiotic maturation of Xenopus laevis (African clawed frog) oocytes, rescues the phenotype of Saccharomyces cerevisiae (budding yeast) CDC5 mutants, and exhibits cell cycle phase-specific kinase activity. Protein serine/threonine kinase maintains a tightly regulated cell cycle expression pattern, and sustains the growth and survival of mycobacteria. Protein serine/threonine kinase can be used in studies related to tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 9026-43-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Protein serine/threonine kinase phosphorylates the forkhead-associated domain-containing protein GarA in vitro[1].
Protein serine/threonine kinase mediates the phosphorylation of 21 unique phosphopeptides in M. bovis BCG cells, a result identified by label-free quantitative ex vivo phosphoproteomics technology[1].
Protein serine/threonine kinase mediates the phosphorylation of 46 intracellular candidate substrates of Mycobacterium tuberculosis, a conclusion drawn from phosphoproteomic analysis combined with small-molecule inhibitors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xenopus laevis (female, stage 5-6 oocytes)[2]
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Dosage:50 ng full-length prk sense transcripts; 50 ng prk antisense transcripts; 50 ng truncated prk (Prk-st) sense transcripts
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Administration:microinjected; single dose
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Result:Showed 100% GVBD in progesterone-treated oocytes.
Showed ~40% GVBD in progesterone-treated oocytes, with maturation first observed 9 hours post-progesterone treatment (vs. 5 hours for vehicle-injected controls).
Showed ~60% GVBD in progesterone-treated oocytes.
Chemical Information
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CAS No. 9026-43-1
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Appearance Solid
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Color Off-white to light brown
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SMILES
[Protein serine/threonine kinase]
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Synonyms
Ser/Thr protein kinase
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Baros SS, et al. Phosphoproteomic Approaches to Discover Novel Substrates of Mycobacterial Ser/Thr Protein Kinases. Mol Cell Proteomics. 2020;19(2):233-244. [Content Brief]
[2]. Ouyang B, et al. Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. J Biol Chem. 1997 Nov 7;272(45):28646-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protein serine/threonine kinase Related Classifications
HY-P2948 Related Classifications
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