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Staphylococcus aureus FabI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (5) Bacterial (6) Reference Standards (1)
By Research Areas:	Infection (6) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16911

AFN-1252 10+ Cited Publications API-1252; Debio 1452	Bacterial Antibiotic	Infection
AFN-1252 is an orally active and selective inhibitor of *FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus* spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC₉₀ values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .

HY-111071

Nilofabicin CG-400549	Bacterial Antibiotic	Infection Inflammation/Immunology
Nilofabicin is an enoyl-(acyl-carrier protein) reductase (FabI) inhibitor. Nilofabicin had an MIC(90) of 0.5 microg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin .

HY-124199

Cephalochromin	Antibiotic Bacterial	Infection
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL .

HY-114622

AFN-1252 tosylate API-1252 tosylate; Debio 1452 tosylate	Bacterial Antibiotic	Infection
AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of *FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus* spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC₉₀ values of 0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .

HY-16911R

AFN-1252 (Standard) API-1252 (Standard); Debio 1452 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Apramycin (Standard) is the analytical standard of Apramycin. This product is intended for research and analytical applications. 0

HY-N19293

Aquastatin C	Bacterial	Infection
Aquastatin C is a glycoaromatic derivative that can be found in Sporothrix sp. FN611. Aquastatin C is a substance that neither regulates bacterial enzymes nor inhibits bacterial growth .

Cephalochromin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL .

Aquastatin C	Structural Classification Monophenols Microorganisms Phenols Source Classification	Bacterial
Aquastatin C is a glycoaromatic derivative that can be found in Sporothrix sp. FN611. Aquastatin C is a substance that neither regulates bacterial enzymes nor inhibits bacterial growth .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Staphylococcus aureus FabI

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Natural
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