Cephalochromin
Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL.
For research use only. We do not sell to patients.
- CAS No.: 25908-26-3
- Formula: C28H22O10
- Molecular Weight:518.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Antibiotic Isoforms
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Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.72 μM
Compound: Cephalochromin
|
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
|
[PMID: 24588135] |
| A549 | IC50 |
5.22 μM
Compound: Cephalochromin
|
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
| BHK-21 | IC50 |
20 μM
Compound: Cephalochromin
|
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
|
[PMID: 15387654] |
| Caco-2 | IC50 |
12.4 μM
Compound: Cephalochromin
|
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
| Hep 3B2 | IC50 |
14.31 μM
Compound: Cephalochromin
|
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
| HT-1080 | IC50 |
4.98 μM
Compound: Cephalochromin
|
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
| Huh-7 | IC50 |
4.64 μM
Compound: Cephalochromin
|
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
| SW1353 | IC50 |
3.54 μM
Compound: Cephalochromin
|
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay
|
[PMID: 24588135] |
Chemical Information
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CAS No. 25908-26-3
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Molecular Weight 518.47
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Formula C28H22O10
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SMILES
OC(C(C(C=C1O[C@@H](C2)C)=[C@@](C(O)=C3)[C@@](C(O)=C4)=C(C=C5O[C@@H](C6)C)C(C(O)=C5C6=O)=C4O)=C3O)=C1C2=O
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Structure Classification
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Initial Source
Cephalosporium caerulens
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)