25908-26-3
Chemical Structure
Cephalochromin
- CAS No.: 25908-26-3
- Formula:C28H22O10
- Molecular Weight:518.47
IUPAC Name: (2R,2'R,9S)-5,5',6,6',8,8'-hexahydroxy-2,2'-dimethyl-2,2',3,3'-tetrahydro-4H,4'H-[9,9'-bibenzo[g]chromene]-4,4'-dione
InChIKey: JGQBYBXYRUCBQY-NXEZZACHSA-N
SMILES: OC(C(C(C=C1O[C@@H](C2)C)=[C@@](C(O)=C3)[C@@](C(O)=C4)=C(C=C5O[C@@H](C6)C)C(C(O)=C5C6=O)=C4O)=C3O)=C1C2=O
Biological Activity: Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL[1].
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Cephalochromin | Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC50 of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL. | |||||||||||||||||||||
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Keywords
