Thyrotropin-Releasing Hormone (TRH),

By Targets:	Thyroid Hormone Receptor (12) TSH Receptor (1) Amino Acid Derivatives (1) Apoptosis (3) Biochemical Assay Reagents (2) Endogenous Metabolite (3) Fluorescent Dye (1) Isotope-Labeled Compounds (1) Prolyl Endopeptidase (PREP) (2)
By Research Areas:	Cancer (2) Endocrinology (10) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (10)

Targets Recommended: Thyroid Hormone Receptor PTHR GHR Nuclear Hormone Receptor 4A/NR4A TSH Receptor MCHR1 (GPR24) GHSR Hormone-Sensitive Lipase (HSL) GnRH Receptor

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-P0002

Protirelin 4 Publications Verification Thyrotropin-Releasing-Hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-B0596

Taltirelin 1 Publications Verification TA-0910	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a **TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀** value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-P0002A

Protirelin acetate 4 Publications Verification Thyrotropin-Releasing-Hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of *TRH* in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-B0596A

Taltirelin acetate 1 Publications Verification TA-0910 acetate	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a **TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀** value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-P10485

Glp-Asn-Pro-AMC	Thyroid Hormone Receptor	Neurological Disease
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a K_i value of 0.97 μM .

HY-P3962

[Phe2]-TRH	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

HY-15113A

Y-29794 tosylate	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .

HY-W009673

Boc-Pyr-OH N-Boc-L-pyroglutamic acid	Amino Acid Derivatives Biochemical Assay Reagents	Others
Boc-Pyr-OH is a Boc-protected pyroglutamic acid derivative. Boc-Pyr-OH stabilizes the amino group of pyroglutamic acid through the Boc protecting group, preventing unwanted reactions during peptide synthesis. Boc-Pyr-OH can be used in the research of thyrotropin-releasing hormone (TRH) synthesis .

HY-P4367

TRH-AMC	Fluorescent Dye	Others
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .

HY-P3969

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release .

HY-19154

Montirelin NS 3	Thyroid Hormone Receptor	Neurological Disease
Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS) .

HY-118117

Rovatirelin S0373	Thyroid Hormone Receptor	Endocrinology
Rovatirelin is an orally active **thyrotropin-releasing hormone (TRH)** analog. Rovatirelin binds to the human TRH receptor with a K_i value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .

HY-107380A

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

HY-117178

TA 0910 acid-type	Thyroid Hormone Receptor	Metabolic Disease
TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH) .

HY-B0596S

Taltirelin-13C,d3 TA-0910-¹³C,d₃	Isotope-Labeled Compounds Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at **thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀** of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

HY-15113

Y-29794	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) .

HY-106744

Azetirelin YM-14673	Biochemical Assay Reagents	Metabolic Disease
Azetirelin (YM-14673) is an analogue of thyrotropin-releasing hormone (TRH) .

Art. -Nr.	Produktname	Type

HY-W009673

Boc-Pyr-OH N-Boc-L-pyroglutamic acid	Biochemical Assay Reagents
Boc-Pyr-OH is a Boc-protected pyroglutamic acid derivative. Boc-Pyr-OH stabilizes the amino group of pyroglutamic acid through the Boc protecting group, preventing unwanted reactions during peptide synthesis. Boc-Pyr-OH can be used in the research of thyrotropin-releasing hormone (TRH) synthesis .

Art. -Nr.	Produktname	Target	Research Area

HY-P1529

Thyrotropin-Releasing Hormone (TRH), Free Acid 2 Publications Verification TRH-OH	Peptides	Neurological Disease Metabolic Disease
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.

HY-P0002

Protirelin 4 Publications Verification Thyrotropin-Releasing-Hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P0002A

Protirelin acetate 4 Publications Verification Thyrotropin-Releasing-Hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of *TRH* in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-P10485

Glp-Asn-Pro-AMC	Thyroid Hormone Receptor	Neurological Disease
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a K_i value of 0.97 μM .

HY-P3962

[Phe2]-TRH	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

HY-P4367

TRH-AMC	Fluorescent Dye	Others
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .

HY-P3969

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release .

HY-107380A

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-P0002

Protirelin 4 Publications Verification Thyrotropin-Releasing-Hormone; TRH	Natürliche Produkte Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Thyroid Hormone Receptor Endogenous Metabolite
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-P3960

(Glu2)-TRH	Natürliche Produkte Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Thyroid Hormone Receptor Endogenous Metabolite
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of *TRH* in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

Art. -Nr.	Produktname	Chemical Structure

HY-B0596S

Taltirelin-13C,d3
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at **thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀** of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P811191

	TRHR Antibody Thyrotropin-Releasing Hormone receptor, TRH-R, Thyroliberin receptor, TRHR	WB, ICC/IF	Human, Mouse, Rat
	TRHR Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to TRHR.

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