[Phe2]-TRH
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin.
For research use only. We do not sell to patients.
- CAS No.: 34783-35-2
- Formula: C19H24N4O4
- Molecular Weight:372.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[Phe2]-TRH Chemical Structure](https://file.medchemexpress.com/product_pic/hy-p3962.gif "Click to View [Phe2]-TRH Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
[Phe2]-TRH has a lower affinity for the TRH receptor than TRH itself, and the substitution of azPro for Pro in the [Phe2, azPro3]-TRH analogue causes an approximately 200-fold further loss in affinity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 34783-35-2
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Molecular Weight 372.42
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Formula C19H24N4O4
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Sequence Shortening
Glp-FP-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Eckle E, et al. Conformational properties of central nervous system active thyrotropin releasing hormone analogues: probing structure-activity relationships at the molecular level. J Med Chem. 1985 Jan;28(1):125-37. [Content Brief]
[2]. Zhang WJ, et al. Impact of azaproline on amide cis-trans isomerism: conformational analyses and NMR studies of model peptides including TRH analogues. J Am Chem Soc. 2003 Feb 5;125(5):1221-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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