Prepro-TRH-(160-169) 

Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release^[1].

In primary cultures of rat anterior pituitary cells, Prepro-TRH-(160-169) (Ps4) is able to increase intracellular Ca²⁺ concentration ([Ca²⁺]_i) rapidly, in 15 s^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In urethane-anesthetized rats, Prepro-TRH-(160-169) (Ps4; 100 ng, 150 ng and 200 ng; injected into dorsal motor nucleus (DMN)) potentiates TRH in the DMN-evoked gastric acid secretion through an action that is peptide and site specific^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1198.30

C₅₄H₇₅N₁₁O₁₈S

122018-91-1

SFPWMESDVT

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6.  [Content Brief]

  [2]. J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97.  [Content Brief]