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Cat. No.: HY-P3969

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Prepro-TRH-(160-169)

Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release.

For research use only. We do not sell to patients.

CAS No.: 122018-91-1
Formula: C₅₄H₇₅N₁₁O₁₈S
Molecular Weight:1198.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Prepro-TRH-(160-169) Chemical Structure

CAS No.: 122018-91-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release^[1].

In Vitro

In primary cultures of rat anterior pituitary cells, Prepro-TRH-(160-169) (Ps4) is able to increase intracellular Ca²⁺ concentration ([Ca²⁺]_i) rapidly, in 15 s^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In urethane-anesthetized rats, Prepro-TRH-(160-169) (Ps4; 100 ng, 150 ng and 200 ng; injected into dorsal motor nucleus (DMN)) potentiates TRH in the DMN-evoked gastric acid secretion through an action that is peptide and site specific^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 122018-91-1
Molecular Weight 1198.30
Formula C₅₄H₇₅N₁₁O₁₈S
Sequence Shortening

SFPWMESDVT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6. [Content Brief]

[2]. J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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