2. Search Result
Search Result
Results for "

enantiomeric

" in MedChemExpress (MCE) Product Catalog:

20

阻害剤およびアゴニスト

2

天然物

2

オリゴヌクレオチド

製品番号 製品名 Target 研究分野 構造式
  • HY-103237
    L-Adenosine

    		Adenosine Deaminase Neurological Disease
    L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .
    L-Adenosine
  • HY-130494
    (±)11(12)-EET

    11,12-EET

    		 NOD-like Receptor (NLR) Cardiovascular Disease Inflammation/Immunology
    (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective .
    (±)11(12)-EET
  • HY-132184
    5,6-Epoxyeicosatrienoic acid

    5,6-EET; (±)5,6-EpETrE

    		 Adrenergic Receptor Calcium Channel Endocrinology
    5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2.
    5,6-Epoxyeicosatrienoic acid
  • HY-101027A
    GSK4028
    1 Publications Verification

    		 Epigenetic Reader Domain Histone Acetyltransferase Inflammation/Immunology Cancer
    GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
    GSK4028
  • HY-106587A
    Octoclothepin maleate salt

    Clorotepine maleate salt

    		 Drug Derivative 5-HT Receptor Neurological Disease
    Octoclothepine (Clorotepine) maleate salt, an analog of Clozapine (HY-14539), is a neuroleptic and antipsychotic agent. Octoclothepine maleate salt exists in enantiomeric forms, where the (+)-form acts as an atypical antipsychotic, while the (-)-functions as a typical antipsychotic. (+)-Octoclothepine maleate salt exhibits extremely high binding affinity for 5-HT₆ and 5-HT₇ receptors, with Ki values of 0.41 and 0.38 nM; the Ki values of (-)-Octoclothepine maleate salt are 17.7 and 1.3 nM, respectively. Octoclothepine maleate salt can be used in research related to schizophrenia .
    Octoclothepin maleate salt
  • HY-N12962
    11S(12R)-EET

    		Others Others
    11S(12R)-EET is a dominant enantiomer of epoxytrienoic acid (EET) that is metabolized at a higher rate in rat organs. It shows enantiomeric-dependent reaction selectivity in hydration, especially in the case of 11,12-EET, where water addition is non-regioselective, while in 8,9-EET, water addition occurs mainly at the C9 position. In addition, 11S(12R)-EET generates diol products with specific stereochemistry through enzymatic hydration reactions, which are affected by the selective recognition of epoxidases, reaction conversion rates, and substrate binding parameters .
    11S(12R)-EET
  • HY-111224
    GSK812397

    		HIV CXCR Infection
    GSK812397 is a CXCR4 antagonist with potential for the treatment of HIV infection. To evaluate the clinical potential of GSK812397, kilogram-scale agent candidates are needed. Here, an improved, scalable synthetic route for the CXCR4 antagonist GSK812397 is described. This new route has been scaled up in a 50-liter stationary facility to obtain 1.2 kg of agent substance in 20% overall yield and >99% chemical and enantiomeric purity in five steps. CXC chemokine receptor 4 (CXCR4) is a 7-transmembrane protein that functions in part as a host co-receptor for multiple strains of HIV-1. It is thought that targeting CXCR4 will help inhibit the replication of several late cytopathic viruses; therefore, CXCR4 antagonists are one of the most promising new classes of experimental anti-HIV agents. GSK812397 is a potent CXCR4 antagonist and is therefore a candidate for investigation for the treatment of HIV infection.
    GSK812397
  • HY-W250446
    (R)-Methyl 3-hydroxydecanoate

    		Biochemical Assay Reagents Others
    (R)-Methyl 3-hydroxydecanoate is an enantiomerically pure hydroxylated fatty acid methyl ester. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
    (R)-Methyl 3-hydroxydecanoate
  • HY-W291165
    D-DABA

    D-2,4-Diaminobutyric acid

    		 GABA Receptor Neurological Disease
    D-DABA is the enantiomeric form of L-DABA. D-DABA is also a weak inhibitor of GABA-T, but which has only one twentieth of the potency of the L-isomer in inhibiting GABA uptake.
    D-DABA
  • HY-130671B
    (S,S)-DPPG

    (S,S)-1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol sodium

    		 Liposome Others
    (S,S)-DPPG is an enantiomeric isomer of L-DPPG. L-DPPG ((R)-1,2-Dipalmitoyl-sn-glycero-3-phosphoglycerol (sodium)) is a phospholipid targeting biological membranes. L-DPPG interacts with lipid bilayers through hydrophobic and electrostatic interactions. L-DPPG is used in research on drug delivery systems .
    (S,S)-DPPG
  • HY-34849
    (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol

    		Biochemical Assay Reagents Others
    (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol is utilized as a chiral shift reagent for determining enantiomeric ratios. Additionally, (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol can be employed for nuclear magnetic resonance (NMR) optical purity determination .
    (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol
  • HY-129244
    Levamlodipine gentisate

    (S)-Amlodipine gentisate; Levoamlodipine gentisate

    		 Calcium Channel Cardiovascular Disease
    Levamlodipine gentisate ((S)-Amlodipine gentisate) is a pharmacologically active amino ester with calcium channel blocker activity. Levamlodipine gentisate is used as an antihypertensive and antianginal compound. The enantiomeric purity of levamlodipine gentisate can be determined by a fast capillary electrophoresis method. The highest resolution of levamlodipine gentisate reached 9.8, indicating its potential application in compound analysis .
    Levamlodipine gentisate
  • HY-121814A
    (R)-Acenocoumarol

    (R)-Acenocoumarin; (R)-Nicoumalone

    		 VD/VDR Cardiovascular Disease
    (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting and orally active anticoagulant, like Warfarin (HY-B0687), works by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol has a greater in vivo anticoagulant potency than Warfarin. (R)-Acenocoumarol has a single chiral center that produces two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 h) and a slower plasma clearance rate (1.9 L/h) than the (S)-enantiomer, resulting in a stronger in vivo anticoagulant effect.
    (R)-Acenocoumarol
  • HY-150286A
    (R)-SM875

    		Prion Protein Infection
    (R)-SM875 is a degrader targeting the intermediate folding form of prion protein (PrP). (R)-SM875 significantly reduces the PrP level, with an IC50 of 3 μM. (R)-SM875 can be used for the study of prion diseases .
    (R)-SM875
  • HY-103237R
    L-Adenosine (Standard)

    		Reference Standards Adenosine Deaminase Neurological Disease
    L-Adenosine (Standard) is the analytical standard of L-Adenosine (HY-103237). This product is intended for research and analytical applications. L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .
    L-Adenosine (Standard)
  • HY-169872
    17-Hydroxystearic acid

    		Endogenous Metabolite Others
    17-Hydroxystearic acid isolable from Torulopsis magnoliae fermentation oil. 17-Hydroxystearic acid is a saturated C18 ω2-hydroxy fatty acid existing in D- and L-enantiomeric forms .
    17-Hydroxystearic acid
  • HY-101027AR
    GSK4028 (Standard)

    		Epigenetic Reader Domain Reference Standards Histone Acetyltransferase Inflammation/Immunology Cancer
    GSK4028 (Standard) is the analytical standard of GSK4028 (HY-101027A). This product is intended for research and analytical applications. GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
    GSK4028 (Standard)
  • HY-184153
    IMP-2958

    		Drug Isomer Others
    IMP-2958 is an inactive enantiomeric negative control probe with significantly reduced binding to RAB27A/B-Cys123.IMP-2958 serves as a negative control probe for off-target binding in phenotypic assays related to RAB27A/B studies.IMP-2958 functions as a control for stereoselective targeted covalent inhibitors of the RAB27-effector protein-protein interaction .
    IMP-2958
  • HY-106587
    Octoclothepine

    Clorotepine

    		 5-HT Receptor Drug Derivative Neurological Disease
    Octoclothepine (Clorotepine), an analog of Clozapine (HY-14539), is a neuroleptic and antipsychotic agent. Octoclothepine exists in enantiomeric forms, where the (+)-form acts as an atypical antipsychotic, while the (-)-functions as a typical antipsychotic. (+)-Octoclothepine exhibits extremely high binding affinity for 5-HT₆ and 5-HT₇ receptors, with Ki values of 0.41 and 0.38 nM; the Ki values of (-)-Octoclothepine are 17.7 and 1.3 nM, respectively. Octoclothepine can be used in research related to schizophrenia .
    Octoclothepine
  • HY-W076861
    3-Amino-3-(4-methoxyphenyl)propanoic acid

    		Amino Acid Derivatives Infection
    3-Amino-3-(4-methoxyphenyl)propanoic acid is a β-amino acid. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be stereoselectively synthesized using alanine as an amino donor and 3-(4-methoxyphenyl)3-oxopropanoic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be enantiomerically enriched from a racemic mixture using pyruvic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be used for research of bacterial and fungal infections .
    3-Amino-3-(4-methoxyphenyl)propanoic acid

オンラインお問い合わせ

入力情報は安全に管理されます. ※ 必須入力項目.

タイトル

  

国或いは地域 *

お名前 *

 

組纖名 *

デパートメント *

     

メールアドレス *

 

製品名 *

製品番号

  

カスタマ需要量 *

電話番号 *

     

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
製品番号:
数量:
MCE 日本正規代理店: