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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
fatty acid synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "fatty acid synthetase" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
FATP1-IN-1 (compound 5k) is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively .
1
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Acyl coenzyme A synthetase (ACS), namely acetyl coenzyme A synthetase, is often used in biochemical research. Acyl coenzyme A synthetase can catalyze the activation of fatty acids by coenzyme A through a two-step thioesterification reaction to produce acyl coenzyme A, and then participate in a variety of anabolic and catabolic lipid metabolism pathways, and participate in the TCA cycle in aerobic respiration .
Cat. No.: HY-B2004
CAS No.: 130000-40-7
Research Areas:
Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .
Cat. No.: HY-173432
CAS No.: 3111845-07-6
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Research Areas:
LIBX-A401 is a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor with a human IC50 values of 0.38 μM and a Kd of 0.72 μM. LIBX-A401 binds to ACSL4 in an ATP-dependent manner, stabilizes the C-terminal domain, alters the fatty acid gate region, and interacts with residues A329 and Q302 within the fatty acid binding site. LIBX-A401 exhibits anti-ferroptosis properties in cells. LIBX-A401 can be used for the researches of cancer and parkinson's disease .
Synonyms: ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%
Cat. No.: HY-E70277
CAS No.: 71425-89-3
Research Areas:
Hexadecyl-CoA is a non-hydrolyzable thioether analog of Palmitoyl-CoA. Hexadecyl-CoA competitively inhibits the acyl-CoA thioesterase activity of HNF-4α with a Ki of 0.3 μM, and inhibits DGAT2 activity with an IC50 of approximately 2 μM. Hexadecyl-CoA also inhibits ATGL activity and serves as a reference inhibitor for DGAT2 LC/MS enzyme activity assays. Hexadecyl-CoA can be used in studies related to lipid metabolism, triglyceride synthesis and lipolysis .
Cat. No.: HY-125140
CAS No.: 24880-40-8
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Research Areas:
ω-3 Arachidonic acid is a poly fatty acid that is essential for growth and development in infants. ω-3 Arachidonic acid inhibits arachidenol-CoA synthetase with Ki values of 14 µM. It also inhibited arachidenol-CoA synthetase of calf brain extract with IC50 values of about 5 µM .
Synonyms: Linoleoyl Coenzyme A; 9(Z),12(Z)-Octadecadienoyl Coenzyme A; 9Z,12Z-Octadecadienoyl-CoA; 9Z,12Z-Octadecadienoyl-coenzyme A
Target:
Research Areas:
Linoleoyl-CoA (Linoleoyl Coenzyme A) is a long-chain acyl-CoA ester formed from linoleic acid and coenzyme A. Linoleoyl-CoA serves as a key activated fatty acid intermediate involved in lipid biosynthesis, fatty acid β-oxidation and the regulation of cellular metabolism. Elevated levels of Linoleoyl-CoA in skeletal muscle correlate with increased lipid availability, insulin resistance and metabolic dysregulation and can be used for activity assays of acyl-CoA synthetases, acyltransferases and fatty acid metabolic enzymes .
Cat. No.: HY-E70241
CAS No.: 157786-88-4
Target:
Research Areas:
3-Hydroxypropionyl-CoA is a metabolic intermediate and enzyme substrate/product that functions in multiple metabolic pathways. 3-Hydroxypropionyl-CoA serves as a substrate for 3-Hydroxypropionyl-CoA dehydratase (HY-E71752), a product of 3-hydroxypropionyl-CoA synthetase, and a hydrolysis substrate for Ehd3p. 3-Hydroxypropionyl-CoA participates in autotrophic CO2 fixation, modified β-oxidation, and reverse hydration reactions. Accumulation of 3-Hydroxypropionyl-CoA inhibits fatty acid β-oxidation at the Fox2p site and induces metabolic toxicity. 3-Hydroxypropionyl-CoA can be used in studies of hematogenously disseminated candidiasis .
Cat. No.: HY-179473
CAS No.: 690257-74-0
Target:
Research Areas:
MK-0626 is a selective, orally active DPP-4 inhibitor with an IC50 of 6.3 nM. MK-0626 increases endothelial nitric oxide synthetase expression. MK-0626 improves neovascularization, attenuates hepatic steatosis, attenuates pancreatic islet injury. MK-0626 can be used in the research of diabetes and non-alcoholic fatty liver disease .
Cat. No.: HY-P86763
Synonyms: ACS2 antibody; ACS5 antibody; Acyl CoA synthetase 5 antibody; Acyl CoA synthetase long chain family member 5 antibody; EC 6.2.1.3 antibody; FACL5 antibody; FACL5 for fatty acid coenzyme A ligase 5 antibody; fatty acid CoA ligase, long chain 5 antibody; fatty acid coenzyme A ligase 5 antibody; fatty acid Coenzyme A ligase long chain 5 antibody; ACS2 antibody; ACS5 antibody; Acyl CoA synthetase 5 antibody; Acyl CoA synthetase long chain family member 5 antibody; EC 6.2.1.3 antibody; FACL5 antibody; FACL5 for fatty acid coenzyme A ligase 5 antibody; fatty acid CoA ligase, long chain 5 antibody; fatty acid coenzyme A ligase 5 antibody; fatty acid Coenzyme A ligase long chain 5 antibody; LACS 5 antibody; Long chain acyl CoA synthetase 5 antibody; Long chain fatty acid CoA ligase 5 antibody; Long chain fatty acid coenzyme A ligase 5 antibody;
Cat. No.: HY-P2832B
Target:
Research Areas:
Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) belongs to the ligase family and can activate the breakdown of complex fatty acids. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) catalyzes the production of fatty acyl-CoA in a two-step process via an adenylate intermediate. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) catalyzes the pre-reaction of fatty acid β-oxidation and can also be incorporated into phospholipids. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) protein is involved in regulating and promoting the transport of long-chain fatty acids in mammalian cells.
Cat. No.: HY-P77206
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC27A4; Acyl-CoA synthetase Very Long Chain Family Member 4; Solute Carrier Family 27 Member 4; Very Long-Chain Acyl-CoA synthetase 4; ACSVL4; Long-Chain-fatty-acid--CoA Ligase; FATP4; fatty acid Transport Protein 4; Long-Chain fatty acid Transport Prote
Species:
Human
Source:
HEK293
Cat. No.: HY-P86762
Synonyms: ACS3 antibody; Acsl3 antibody; ACSL3_HUMAN antibody; Acyl CoA synthetase long chain family member 3 antibody; FACL3 antibody; fatty acid Coenzyme A ligase long chain 3 antibody; LACS 3 antibody; LACS3 antibody; Lignoceroyl CoA synthase antibody; Long chain acyl CoA synthetase 3 antibody; ACS3 antibody; Acsl3 antibody; ACSL3_HUMAN antibody; Acyl CoA synthetase long chain family member 3 antibody; FACL3 antibody; fatty acid Coenzyme A ligase long chain 3 antibody; LACS 3 antibody; LACS3 antibody; Lignoceroyl CoA synthase antibody; Long chain acyl CoA synthetase 3 antibody; Long chain fatty acid CoA ligase 3 antibody; Long-chain acyl-CoA synthetase 3 antibody; Long-chain-fatty-acid--CoA ligase 3 antibody; PRO2194 antibody;
Cat. No.: HY-P811681
Synonyms: ACSVL1, FACVL1, FATP2, VLACS, SLC27A2, Long-chain fatty acid transport protein 2, Arachidonate--CoA ligase, fatty acid transport protein 2, Long-chain-fatty-acid--CoA ligase, Phytanate--CoA ligase, Solute carrier family 27 member 2, THCA-CoA ligase, Very long-chain acyl-CoA synthetase, Very long-chain-fatty-acid-CoA ligase, FATP-2, VLCS
Cat. No.: HY-P701891
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ACSL1; Lignoceroyl-CoA Synthase; Prev. FACL2; Palmitoyl-CoA Ligase 1; LACS2; Palmitoyl-CoA Ligase 2; LACS1; Acyl-CoA synthetase 1; FACL1; Phytanate--CoA Ligase; LACS; LACS 1; ACS1; LACS 2; fatty-acid-Coenzyme A Ligase, Long-Chain 2; fatty-acid-Coenzyme A
Species:
Others
Source:
E. coli
Cat. No.: HY-P701892
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ACSL1; Lignoceroyl-CoA Synthase; Prev. FACL2; Palmitoyl-CoA Ligase 1; LACS2; Palmitoyl-CoA Ligase 2; LACS1; Acyl-CoA synthetase 1; FACL1; Phytanate--CoA Ligase; LACS; LACS 1; ACS1; LACS 2; fatty-acid-Coenzyme A Ligase, Long-Chain 2; fatty-acid-Coenzyme A
Species:
Others
Source:
E. coli
Cat. No.: HY-P704210
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACSL1; Lignoceroyl-CoA Synthase; Prev. FACL2; Palmitoyl-CoA Ligase 1; LACS2; Palmitoyl-CoA Ligase 2; LACS1; Acyl-CoA synthetase 1; FACL1; Phytanate--CoA Ligase; LACS; LACS 1; ACS1; LACS 2; fatty-acid-Coenzyme A Ligase, Long-Chain 2; fatty-acid-Coenzyme A
Species:
Human
Source:
E. coli
Cat. No.: HY-P705521
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ACSL1; Lignoceroyl-CoA Synthase; Prev. FACL2; Palmitoyl-CoA Ligase 1; LACS2; Palmitoyl-CoA Ligase 2; LACS1; Acyl-CoA synthetase 1; FACL1; Phytanate--CoA Ligase; LACS; LACS 1; ACS1; LACS 2; fatty-acid-Coenzyme A Ligase, Long-Chain 2; fatty-acid-Coenzyme A
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
