2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Dipeptidyl Peptidase NO Synthase
  4. MK-0626

MK-0626 is a selective, orally active DPP-4 inhibitor with an IC50 of 6.3 nM. MK-0626 increases endothelial nitric oxide synthetase expression. MK-0626 improves neovascularization, attenuates hepatic steatosis, attenuates pancreatic islet injury. MK-0626 can be used in the research of diabetes and non-alcoholic fatty liver disease.

For research use only. We do not sell to patients.

MK-0626

MK-0626 Chemical Structure

CAS No. : 690257-74-0

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MK-0626 Related Antibodies

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

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nNOS iNOS eNOS

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Description

MK-0626 is a selective, orally active DPP-4 inhibitor with an IC50 of 6.3 nM. MK-0626 increases endothelial nitric oxide synthetase expression. MK-0626 improves neovascularization, attenuates hepatic steatosis, attenuates pancreatic islet injury. MK-0626 can be used in the research of diabetes and non-alcoholic fatty liver disease[1][2][3].

IC50 & Target[1][21][3]

DPP-4

6.3 nM (IC50)

Molecular Weight

442.46

Formula

C22H24F2N6O2
CAS No.
SMILES

O=C(N1CC(F)(CC1)F)[C@@H](N)[C@H](C2=CC=C(C3=CN4C(C=C3)=NC=N4)C=C2)C(N(C)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK-0626 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0626690257-74-0MK0626MK 0626Dipeptidyl PeptidaseNO SynthaseDPPNitric oxide synthasesNOSdiabetesnon-alcoholic fatty liver diseaseInhibitorinhibitorinhibit

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