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Results for "

fer-

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Peptides

1

Recombinant Proteins

4

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100579
    Ferrostatin-1
    Maximum Cited Publications
    1548 Publications Verification

    fer-1

    		 Ferroptosis Fungal Cancer
    Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .
    Ferrostatin-1
  • HY-122844
    Ifebemtinib
    3 Publications Verification

    BI-853520; IN-10018

    		 FAK Cancer
    Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC50s of 900 nM and 1040 nM, respectively .
    Ifebemtinib
  • HY-112097
    E260
    3 Publications Verification

    		 EGFR Cancer
    E260 is a Fer/FerT kinase inhibitor.
    E260
  • HY-123919
    TL13-112
    2 Publications Verification

    		 PROTACs Anaplastic lymphoma kinase (ALK) Cancer
    TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib?(HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984) .
    TL13-112
  • HY-122582
    TL13-12

    		PROTACs Anaplastic lymphoma kinase (ALK) Cancer
    TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) .
    TL13-12
  • HY-148061
    DB1113

    		PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK) Cancer
    DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .
    DB1113
  • HY-128576
    DS21360717
    2 Publications Verification

    		 EGFR Cancer
    DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity .
    DS21360717
  • HY-148063
    DB0614

    		PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) LIM Kinase (LIMK) ULK Metabolic Disease
    DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .(Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070))
    DB0614
  • HY-156066
    Ferrostatin-1 diyne

    fer-1 diyne

    		 Ferroptosis Cancer
    Ferrostatin-1 diyne (Fer-1 diyne) (compound 2) is a ferroptosis inhibitor that accumulates in lysosomes, mitochondria, and endoplasmic reticulum in cells, but its inhibition of ferroptosis is not dependent on the activity of lysosomes and mitochondria.
    Ferrostatin-1 diyne
  • HY-RS16564
    Fer Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fer Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fer gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fer Mouse Pre-designed siRNA Set A
    Fer Mouse Pre-designed siRNA Set A
  • HY-10338A
    Foretinib phosphate

    		c-Met/HGFR VEGFR Cancer
    Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB .
    Foretinib phosphate
  • HY-P10229
    RALF1 peptide

    		Phytohormone Others
    RALF1 peptide, a polypeptide found in plant kingdom (as well as in fungi and bacteria), is a FERONIA (FER) modulator. RALF1 peptide mediates rapid net H + influx across the plasma membrane, apoplast alkalinization, rapid reversible root growth inhibition, and non-transcriptional regulation.RALF1 peptide up-regulates auxin biosynthesis genes, activates canonical TIR1/AFB auxin signaling, and mediates sustained root growth inhibition. RALF1 peptide can be used for research on the regulation of plant growth and development .
    RALF1 peptide
  • HY-RS04862
    FER Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FER Human Pre-designed siRNA Set A contains three designed siRNAs for FER gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FER Human Pre-designed siRNA Set A
    FER Human Pre-designed siRNA Set A
  • HY-RS22996
    Fer Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fer Rat Pre-designed siRNA Set A contains three designed siRNAs for Fer gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fer Rat Pre-designed siRNA Set A
    Fer Rat Pre-designed siRNA Set A
  • HY-RS04863
    FER1L6 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FER1L6 Human Pre-designed siRNA Set A contains three designed siRNAs for FER1L6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FER1L6 Human Pre-designed siRNA Set A
    FER1L6 Human Pre-designed siRNA Set A
  • HY-161731
    DS08701581

    		EGFR Cancer
    DS08701581 is an inhibitor of FER tyrosine kinase with IC50. DS08701581 has anti-tumor activity and oral activity .
    DS08701581
  • HY-100579R
    Ferrostatin-1 (Standard)

    fer-1 (Standard)

    		 Ferroptosis Reference Standards Fungal Cancer
    Ferrostatin-1 (Standard) is the analytical standard of Ferrostatin-1 (HY-100579). This product is intended for research and analytical applications. Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .
    Ferrostatin-1 (Standard)

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