FER Antibody (YA4850)
(Synonyms: FER; TYK3; Tyrosine-protein kinase Fer; Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer)FER Antibody (YA4850) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FER.
-
Host:
Mouse
-
Application:
WB, IHC-P, ICC/IF, ELISA
-
Reactivity :
Human, Mouse
-
Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
FER Antibody (YA4850) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FER.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse
-
Calculated Molecular Weight Predicted band size: 95 kDa;
Purified recombinant fragment of human Fer expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
FER is a Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus
-
Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cell projection; Cell junction; Membrane; Peripheral membrane protein; Cytoplasmic side; Nucleus; Cytoplasm, cell cortex
-
Expression
Tissue_specificity:Isoform 1 is detected in normal colon and in fibroblasts (at protein level) . Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level) . Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level) . Widely expressed -
Isoforms & Post-Translational Modification
P16591 has 3 isomers: P16591-1: 94638 Da (predicted); P16591-2: 74266 Da (predicted); P16591-3: 51643 Da (predicted).
Autophosphorylated;Polyubiquitinated; this leads to proteasomal degradation -
Subunit
Homotrimer. Interacts with ARHGDIA, IRS1, JAK1, NRP1, PIK3R1, PLEC and TMF1.
-
SwissProt ID
-
Synonyms
FER; TYK3; Tyrosine-protein kinase Fer; Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer
Documentation
Powered by Bioz
