glucose-6-phosphate

By Targets:	Endogenous Metabolite (3) PDI (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (5)

Targets Recommended: GLUT PIKfyve SGLT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism	Endogenous Metabolite	Metabolic Disease Cancer
Glucose-6-phosphate dehydrogenase, Microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer .

HY-P2918

Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Others
Phosphoglucose Isomerase, Baker's yeast (S. cerevisiae) (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-W107464

G6PDi-1	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive **glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀** of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-123962

G6PD activator AG1 1 Publications Verification	Others	Metabolic Disease
G6PD activator AG1 is a potent and selective **glucose-6-phosphate dehydrogenase (G6PD) activator with an EC₅₀** of 3 µΜ . G6PD activator AG1 reduces hemolysis of human erythrocytes .

HY-W010342

6-Aminonicotinamide 4 Publications Verification	Others	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme **glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i**=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells .

HY-P2820

Phosphoglucomutase, Rabbit muscle	Endogenous Metabolite	Metabolic Disease
Phosphoglucomutase, Rabbit muscle is often used in biochemical studies. Phosphoglucomutase is an enzyme that can transfer the phosphate group on the α-D-glucose monomer forward from the 1-position to the 6-position or reversely transfer from the 6-position to the 1-position, and promote the glucose-1-phosphate and glucose-6-phosphate Transform each other. Phosphoglucomutase is a key enzyme in glycolysis and gluconeogenesis, and plays an important role in the metabolism of proteins, lipids and nucleic acids .

HY-120872

AJS1669 free acid	Others	Metabolic Disease
AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	689 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 689 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

689 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 689 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Glucose-6-phosphate dehydrogenase, Microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer .

Species:	Human (3) Mouse (2)
Tag:	His (5) MBP (1) Flag (1) B2M (1)
Source:	HEK293 (1) P. pastoris (1) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71738

	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) Gpi; Gpi1glucose-6-phosphate isomerase; GPI; AMF; Neuroleukin; NLK; PHI	Mouse	P. pastoris
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is 557 a.a., with molecular weight of ~64.6 kDa.

HY-P70283

	G6PD Protein, Human (HEK293, His) rHuglucose-6-phosphate 1-dehydrogenase/G6PD, His; glucose-6-phosphate 1-Dehydrogenase; G6PD	Human	HEK293
	G6PD proteins play a key role in cellular metabolism by catalyzing the rate-limiting step of the oxidative pentose phosphate pathway, which is essential for carbohydrate dissimilation during glycolysis. The primary function of this enzyme is to provide reducing power in the form of NADPH and generate pentose phosphate, supporting essential processes such as fatty acid and nucleic acid synthesis. G6PD Protein, Human (HEK293, His) is the recombinant human-derived G6PD protein, expressed by HEK293 , with C-6*His labeled tag. The total length of G6PD Protein, Human (HEK293, His) is 514 a.a., with molecular weight of 55-62 kDa.

HY-P702035

	SLC37A4 Protein, Human (Sf9, His, MBP, FLAG) SLC37A4; glucose-6-phosphate exchanger SLC37A4; glucose-5-phosphate transporter; glucose-6-phosphate translocase; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19	Human	Sf9 insect cells
	SLC37A4 protein, an endoplasmic reticulum antiporter, transports glucose-6-phosphate into the endoplasmic reticulum lumen while moving inorganic phosphate in the opposite direction. This function is integral to glucose production through glycogenolysis and gluconeogenesis, underscoring SLC37A4's central role in regulating blood glucose levels and maintaining metabolic balance. SLC37A4 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC37A4 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC37A4 Protein, Human (Sf9, His, MBP, FLAG) is 428 a.a., .

HY-P72210

	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) Gpi; Gpi1glucose-6-phosphate isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI	Mouse	E. coli
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is 557 a.a., with molecular weight of ~76.6 kDa.

HY-P71680

	Glucose-6-phosphate isomerase Protein, Human (His) AMF; Aurocrine motility factor; Autocrine motility factor; DKFZp686C13233; EC 5.3.1.9; Neuroleukin; NLK; Oxoisomerase; PGI; PHI; Phosphoglucose isomerase; SA-36; SA36; Sperm antigen 36	Human	E. coli
	Glucose-6-phosphate isomerase protein is a key player in glycolysis, catalyzing the conversion of glucose-6-phosphate into fructose-6-phosphate in the cytoplasm. It carries out this reaction reversibly during gluconeogenesis. Glucose-6-phosphate isomerase Protein, Human (His) is the recombinant human-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Human (His) is 553 a.a., with molecular weight of ~65.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80688

Glucose 6 Phosphate Dehydrogenase Antibody G6PD; glucose-6-phosphate 1-dehydrogenase; G6PD	WB, IHC-P, IP	Human, Rat
Glucose 6 Phosphate Dehydrogenase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 59 kDa, targeting to Glucose 6 Phosphate Dehydrogenase. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Rat.

HY-P82032

AMF Antibody (YA1777) GPI; glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human

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