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glucose-6-phosphate-dehydrogenase

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By Targets:	Biochemical Assay Reagents (1) CD38 (1) Drug Metabolite (1) Endogenous Metabolite (9) NADPH Oxidase (3) Neurokinin Receptor (1) Parasite (1) PDI (5) Reference Standards (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (5) Inflammation/Immunology (2) Metabolic Disease (11) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010342

6-Aminonicotinamide Maximum Cited Publications 17 Publications Verification	NADPH Oxidase	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme **glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i**=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .

HY-W107464

G6PDi-1 5+ Cited Publications	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive **glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀** of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-W012530

Phenylpyruvic acid	Endogenous Metabolite PDI	Infection Metabolic Disease
Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce *glucose-6-phosphate dehydrogenase* activity .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism G6PD	Endogenous Metabolite	Metabolic Disease Cancer
Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

HY-123962

G6PD activator AG1 5+ Cited Publications	NADPH Oxidase	Metabolic Disease
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes .

HY-W587796

6-Phosphoglucono-δ-lactone 6-PGδL; 6-Phosphonoglucono-D-lactone	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
6-Phosphoglucono-δ-lactone (6-PGδL), a reversal substrate of glucose-6-phosphate dehydrogenase (G6PD), is an intermediate compound in the oxidative branch of the pentose phosphate pathway (PPP). 6-Phosphoglucono-δ-lactone produced from D-glucose-6-phosphate by glucose-6-phosphate dehydrogenase (G6PDH) and is converted to 6-phosphoglutonate by lactonase. 6-Phosphoglucono-δ-lactone can be used for heart failure, type 2 diabetes and cancers research .

HY-125863C

Glucose-6-phosphate dehydrogenase, Bacillus sp. G6PD, Bacillus sp.	Endogenous Metabolite	Others
Glucose-6-phosphate dehydrogenase, Bacillus sp. catalyzes the conversion of glucose-6-phosphate into 6-phosphogluconolactone, and produces reduced nicotinamide adenine dinucleotide phosphate (NADPH) and ribose-5-phosphate in this process. Glucose-6-phosphate dehydrogenase, Bacillus sp. can be used in research about diabetic complications .

HY-W012530R

Phenylpyruvic acid (Standard)	Reference Standards Endogenous Metabolite PDI	Infection Metabolic Disease
Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce *glucose-6-phosphate dehydrogenase* activity .

HY-W016203

Phenylpyruvic acid sodium Sodium phenylpyruvate	Endogenous Metabolite PDI	Infection Metabolic Disease
Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce *glucose-6-phosphate dehydrogenase* activity .

HY-125863B

Glucose 6-phosphate dehydrogenase (yeast, recombinant) G6PD (yeast, recombinant)	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Cancer
Glucose 6-phosphate dehydrogenase (yeast, recombinant) is the rate-limiting enzyme of the pentose phosphate pathway and a major source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, and cytochrome P450 systems. Glucose 6-phosphate dehydrogenase helps cells resist oxidative stress and regulates metabolic rates. It holds potential for research in fields such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

HY-125863A

Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) G6PD (Leuconostoc sp., recombinant)	Endogenous Metabolite	Metabolic Disease
Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase .

HY-N2093

Vicine 2 Publications Verification	Drug Metabolite	Cardiovascular Disease Metabolic Disease
Vicine, an alkaloid glycoside found mainly in fava beans, is toxic in individuals who have a hereditary loss of the enzyme glucose-6-phosphate dehydrogenase and may cause haemolytic anaemia.Vicine is an inactive compound that is hydrolysed by the intestinal microflora to a highly reactive free radical generating compound, the aglycone divicine when Vicine enters the body through food .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

HY-W010342R

6-Aminonicotinamide (Standard)	NADPH Oxidase Reference Standards	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .

HY-E71039

*Chemically modified Glucose-6-phosphate Dehydrogenase, Leuconostoc mesenteroides*	Biochemical Assay Reagents	Others
Chemically modified Glucose-6-phosphate Dehydrogenase, Leuconostoc mesenteroides is a cytosolic enzyme. Chemically modified Glucose-6-phosphate Dehydrogenase, Leuconostoc mesenteroides is in the pentose phosphate pathway, a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) .

HY-125863D

Glucose-6-phosphate dehydrogenase, Torula yeast	Endogenous Metabolite	Metabolic Disease
Glucose-6-phosphate dehydrogenase, Torula yeast (EC 1.1.1.49), is a cytoplasmic enzyme located in the pentose phosphate pathway, a metabolic pathway that provides reducing energy to cells (e.g., erythrocytes) by maintaining the level of the coenzyme nicotinamide adenine dinucleotide phosphate (NADPH).

HY-W248922

2,6-Dibromo-4-(hydroxymethyl)phenol	PDI	Infection
2,6-Dibromo-4-(hydroxymethyl) phenol (Compound 5) acts as a selective inhibitor of Saccharomyces cerevisiae *glucose-6-phosphate dehydrogenase, with an IC50* value of 50.2 μM, and shows no activity against Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase .

HY-136783

G6PD-IN-2	Parasite	Infection
G6PD-IN-2 is a Plasmodium falciparum *glucose-6-phosphate dehydrogenase* (G6PD) inhibitor with an IC₅₀ value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum *glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase* (PfGluPho) with an IC₅₀ value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria .

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

Phenylpyruvic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite PDI
Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce *glucose-6-phosphate dehydrogenase* activity .

Glucose-6-phosphate dehydrogenase, Microorganism G6PD	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Glucose-6-phosphate dehydrogenase, Microorganism (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase, Microorganism is a primary source of NADPH in antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 systems, and others. Glucose-6-phosphate dehydrogenase, Microorganism is applicable in research related to diabetes, endothelial dysfunction, cancer, and cardiomyopathy .

Phenylpyruvic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Reference Standards Endogenous Metabolite PDI
Phenylpyruvic acid (Standard) is the analytical standard of Phenylpyruvic acid. This product is intended for research and analytical applications. Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce *glucose-6-phosphate dehydrogenase* activity .

Vicine 2 Publications Verification	Alkaloids Classification of Application Fields Leguminosae Other Alkaloids Metabolic Disease Plants Vicia faba L. Disease Research Fields Source Classification	Drug Metabolite
Vicine, an alkaloid glycoside found mainly in fava beans, is toxic in individuals who have a hereditary loss of the enzyme glucose-6-phosphate dehydrogenase and may cause haemolytic anaemia.Vicine is an inactive compound that is hydrolysed by the intestinal microflora to a highly reactive free radical generating compound, the aglycone divicine when Vicine enters the body through food .

Host:	Mouse (4) Rabbit (3)
Reactivity:	Human (7) Rat (3) Mouse (4) Rabbit (2)
Application:	IHC-P (7) ICC/IF (4) IP (2) WB (6) FC (5) ELISA (4)
Isotype:	IgG (3) IgG1 (2) IgG2a (1)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86013

	Glucose 6 Phosphate Dehydrogenase Antibody (YA5705)	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Glucose 6 Phosphate Dehydrogenase Antibody (YA5705) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P84063

	Glucose 6 Phosphate Dehydrogenase Antibody (YA3760) G6PD1	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit
	Glucose 6 Phosphate Dehydrogenase Antibody (YA3760) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P84063A

	Glucose 6 Phosphate Dehydrogenase Antibody (YA3760)(PBS only) G6PD1	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit
	Glucose 6 Phosphate Dehydrogenase Antibody (YA3760) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P80688

	Glucose 6 Phosphate Dehydrogenase Antibody (YA411) G6PD; glucose-6-phosphate 1-dehydrogenase; G6PD	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Glucose 6 Phosphate Dehydrogenase Antibody (YA411) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P85177

	Glucose 6 Phosphate Dehydrogenase Antibody (YA4869) G6PD; glucose-6-phosphate 1-dehydrogenase; G6PD	WB, IHC-P, ICC/IF, FC, ELISA	Human
	Glucose 6 Phosphate Dehydrogenase Antibody (YA4869) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P810629

	Glucose 6 Phosphate Dehydrogenase Antibody (YA9891) G6PD; glucose-6-phosphate 1-dehydrogenase; G6PD	WB, ICC/IF, IHC-P, FC	Human
	Glucose 6 Phosphate Dehydrogenase Antibody (YA9891) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

HY-P80688A

	Glucose 6 Phosphate Dehydrogenase Antibody (YA411)(PBS only) G6PD; glucose-6-phosphate 1-dehydrogenase; G6PD	WB, IHC-P, IP	Human, Rat
	Glucose 6 Phosphate Dehydrogenase Antibody (YA411) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose 6 Phosphate Dehydrogenase.

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glucose-6-phosphate-dehydrogenase

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