Glucose-6-phosphate isomerase Protein, Mouse (His-B2M)
Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag.
Background
Glucose-6-phosphate isomerase protein, localized in the cytoplasm, serves a dual function: it catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, playing a pivotal role in both glycolysis and the reverse reaction during gluconeogenesis. Beyond its enzymatic involvement in metabolic pathways, this protein exhibits additional roles as a secreted cytokine. Functioning as an angiogenic factor (AMF), it stimulates endothelial cell motility, suggesting its participation in angiogenesis. Furthermore, glucose-6-phosphate isomerase acts as a neurotrophic factor known as neuroleukin, specifically influencing spinal and sensory neurons. Notably, it is secreted by lectin-stimulated T-cells, where it induces immunoglobulin secretion. This multifaceted protein showcases its versatility, contributing to both fundamental metabolic processes and exhibiting extracellular functions with implications in angiogenesis, neurotrophic support, and immune responses.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-6*His;B2M
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Accession
P06745 (A2-E558)
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Molecular Construction
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N-term
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6*His-B2M
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GPI (A2-E558)
Accession # P06745 -
C-term
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Protein Length
Full Length
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Synonyms
GPI; PGI; Glucose-6-Phosphate Isomerase; Hexose Monophosphate Isomerase; NLK; Glucose Phosphate Isomerase; AMF; Hexosephosphate Isomerase; Phosphoglucose Isomerase; Phosphosaccharomutase; Phosphohexose Isomerase; Phosphohexomutase; Glucose-6-Phosphate C2-
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AA Sequence
AALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVNKEVMQMLVELAKSRGVEAARDNMFSGSKINYTENRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKLE
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Predicted Molecular Mass
76.6 kDa
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Molecular Weight
Approximately 77 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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