Gpi1 - glucose-6-phosphate isomerase 1 Gene

Also Known as MF; NK; Amf; Gpi; Nlk; Org; Pgi; Phi; Gpi-1; Gpi1s; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14751

Summary

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]

Gpi1 Products (1)

mRNA Protein Name
NM_008155.4 NP_032181.2 glucose-6-phosphate isomerase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucose-6-phosphate isomerase activity IDA
IDA: Inferred from direct assay
204065 MGI
enables glucose-6-phosphate isomerase activity IMP
IMP: Inferred from mutant phenotype
3796661 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17875708 MGI
Biological Process GO Annotation Evidence References Source
involved in GDP-mannose biosynthetic process from glucose IDA
IDA: Inferred from direct assay
21273394 MGI
acts upstream of or within erythrocyte homeostasis IMP
IMP: Inferred from mutant phenotype
8417789 MGI
involved in fructose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
6767907 MGI
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
31891762 MGI
involved in glucose 6-phosphate metabolic process IDA
IDA: Inferred from direct assay
6767907 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
8417789 MGI
acts upstream of or within glycolytic process IDA
IDA: Inferred from direct assay
15665293 MGI
acts upstream of or within glycolytic process IMP
IMP: Inferred from mutant phenotype
8417789 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
1582174 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
8922529 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary membrane IDA
IDA: Inferred from direct assay
22179047 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
6986434 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22179047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glucose-6-phosphate isomerase

  • autocrine motility factor

  • glucose phosphate isomerase 1 complex

  • glucose phosphate isomerase 1, regulatory

  • glucose phosphate isomerase 1, structural

  • glucose phosphate isomerase 1, temporal

  • maturation factor

  • neuroleukin

  • phosphoglucose isomerase

  • phos

Gpi1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gpi P06745 Parp14 Mus musculus Q2EMV9
Y2H
17875708
Intra
Gpi P06745 Parp14 Mus musculus Q2EMV9
Confocal
17875708
Intra
Gpi P06745 Parp14 Mus musculus Q2EMV9
Anti Bait CoIP
17875708
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Gpi1 Proteins

Cat. No. Product Name Accession Purity
HY-P71738 Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) P06745 (A2-E558) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72210 Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) P06745 (A2-E558) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10499 PIGQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22279 Pigq Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23184 Gpi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown