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Results for "

hyperglycemic mice

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131334
    AMPK activator 4

    		AMPK Metabolic Disease
    AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .
    AMPK activator 4
  • HY-W197205
    SL010110

    		Sirtuin Histone Acetyltransferase PEPCK Metabolic Disease
    SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research .
    SL010110
  • HY-10289
    Carmegliptin

    RO-4876904

    		 Dipeptidyl Peptidase GLP Receptor P-glycoprotein Metabolic Disease
    Carmegliptin (RO-4876904) is an orally active and potent DPP IV inhibitor with a human DPP IV IC50 of 6.8 nM. Carmegliptin binds to the S1 pocket of DPP IV, blocks the degradation of GLP 1, potentiates endogenous GLP 1, increases plasma insulin levels, alleviates hyperglycemia, improves glucose tolerance. Carmegliptin acts as a substrate for human P glycoprotein without inhibiting the transporter, shows low in vitro cell permeability. Carmegliptin can be used for the research of type 2 diabetes, non insulin dependent diabetes mellitus .
    Carmegliptin
  • HY-N17761A
    Tetrandrine 2'-N-β-oxide

    		Others Metabolic Disease
    Tetrandrine 2'-N-β-oxide is an anti-hyperglycemic dibenzylisoquinoline alkaloid. At a dose of 1 mg/kg, Tetrandrine 2'-N-β-oxide can reduce hyperglycemia levels in streptozotocin (HY-13753)-induced diabetic mice to nearly 50% of their original levels. Tetrandrine 2'-N-β-oxide is primarily used in research related to the anti-hyperglycemic of type 2 diabetes.
    Tetrandrine 2'-N-β-oxide
  • HY-179729
    α-Glucosidase-IN-106

    		Glycosidase Metabolic Disease
    α-Glucosidase-IN-106 (Compound 17F) is an inhibitor of α-glucosidase with an IC50 of 14.9 μM. α-Glucosidase-IN-106 can effectively inhibit the peak of blood glucose after sucrose loading in normal mice, and shows a more significant anti-hyperglycemic effect in diabetic mice. α-Glucosidase-IN-106 can be used for research on diabetes .
    α-Glucosidase-IN-106

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