PEPCK

Phosphoenolpyruvate Carboxykinase

PEPCK (Phosphoenolpyruvate carboxykinase) is an enzyme in the lyase family used in four pathways: gluconeogenesis, glyceroneogenesis, the synthesis of serine, and the conversion of the carbon skeletons of amino acids. PEPCK is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and is also a key regulator of TCA cycle flux. PEPCK can catalyze oxaloacetate into phosphoenolpyruvate (PEP) and carbon dioxide. PEPCK has two isoforms: PEPCK1 (PEPCK-C) and PEPCK2 (PEPCK-M). PEPCK1/PEPCK2 is distributed in the cytosol and mitochondria, and is overexpressed in many cancers^[1]^[2].

References:

[1]. Yang J, et al. What is the metabolic role of phosphoenolpyruvate carboxykinase? J Biol Chem. 2009 Oct 2;284(40):27025-9. [Content Brief]

[2]. Wang Z, et al. Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase. Trends Cancer. 2019 Jan;5(1):30-45. [Content Brief]

PEPCK Inhibitors (2)

PEPCK Related Products (2):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-128923

SKF-34288 hydrochloride	Inhibitor
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (K_i: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.

HY-N3720

Demethoxycapillarisin	Inhibitor
Demethoxycapillarisin (6-Demethoxycapillarisin) inhibits PEPCK mRNA levels (IC₅₀: 43 μM) by activation of the PI3K pathway. Demethoxycapillarisin decreases glucose production.

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