61854-36-2
Chemical Structure
Demethoxycapillarisin
Synonym(s): 6-Demethoxycapillarisin
- CAS No.: 61854-36-2
- Formula:C15H10O6
- Molecular Weight:286.24
IUPAC Name: 5,7-dihydroxy-2-(4-hydroxyphenoxy)-4H-chromen-4-one
InChIKey: UBSCDKPKWHYZNX-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13
Biological Activity: Demethoxycapillarisin (6-Demethoxycapillarisin) is a natural polyphenolic compound of the benzochromone class. Demethoxycapillarisin inhibits aldose reductase (ALR2); it also downregulates PEPCK transcription, thereby inhibiting hepatic gluconeogenesis, with an IC50 of 43 µM. Demethoxycapillarisin is an active component with pro-adipogenic activity in Artemisia scoparia, and it is speculated to regulate AMPK through a coumarin-related mechanism. Demethoxycapillarisin can be used in diabetes-related research[1][2][3][4].
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Demethoxycapillarisin | 99.93% | Demethoxycapillarisin (6-Demethoxycapillarisin) is a natural polyphenolic compound of the benzochromone class. Demethoxycapillarisin inhibits aldose reductase (ALR2); it also downregulates PEPCK transcription, thereby inhibiting hepatic gluconeogenesis, with an IC50 of 43 µM. Demethoxycapillarisin is an active component with pro-adipogenic activity in Artemisia scoparia, and it is speculated to regulate AMPK through a coumarin-related mechanism. Demethoxycapillarisin can be used in diabetes-related research. | ||||||||||||||||||||
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References
- [1]. Govorko D, et al. Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. American journal of physiology. Endocrinology and metabolism. 2007 Dec;293(6):E1503-10. [Content Brief]
- [2]. Logendra S, et al. Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry. 2006 Jul;67(14):1539-46.
- [3]. Vandanmagsar B, et al. Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov;143:112188.
- [4]. Boudreau A, et al. Distinct fractions of an Artemisia scoparia extract contain compounds with novel adipogenic bioactivity. Frontiers in Nutrition. 2019 Mar 8;6:18.
