Thevetiaflavone  (Synonyms: Apigenin-5-methyl ether)

Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3.

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca²⁺ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

284.26

C₁₆H₁₂O₅

29376-68-9

Solid

Light yellow to yellow

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(OC)=C13

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Yao H, et al. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction. Mol Med Rep. 2017 Dec;16(6):9197-9202.  [Content Brief]