1. Apoptosis
  2. Bcl-2 Family
    Caspase

Thevetiaflavone (Synonyms: Apigenin-5-methyl ether)

Cat. No.: HY-N1157
Handling Instructions

Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3.

For research use only. We do not sell to patients.

Thevetiaflavone Chemical Structure

Thevetiaflavone Chemical Structure

CAS No. : 29376-68-9

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Description

Thevetiaflavone could upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3.

IC50 & Target

Bcl-2

 

Bax

 

Caspase-3

 

In Vitro

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

284.26

Formula

C₁₆H₁₂O₅

CAS No.

29376-68-9

SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=CC(OC)=C13

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Thevetiaflavone
Cat. No.:
HY-N1157
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Thevetiaflavone

Cat. No.: HY-N1157