2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Bax inhibitor peptide V5

Bax inhibitor peptide V5  (Synonyms: BIP-V5; BAX Inhibiting Peptide V5)

Cat. No.: HY-P0081 Purity: 98.28%
COA Handling Instructions

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bax inhibitor peptide V5 Chemical Structure

Bax inhibitor peptide V5 Chemical Structure

CAS No. : 579492-81-2

Size Price Stock Quantity
5 mg USD 119 In-stock
10 mg USD 185 In-stock
25 mg USD 396 In-stock
50 mg USD 660 In-stock
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Customer Review

Based on 16 publication(s) in Google Scholar

Bax inhibitor peptide V5 Related Antibodies

Top Publications Citing Use of Products

    Bax inhibitor peptide V5 purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2018 Sep 15;355:269-285.  [Abstract]

    Bax inhibition ameliorates mitochondria dysfunction through modulating translocation and expression of Bax. H9c2 cells are treated with 160 nM TP for 24 h after pretreatment with BIP V5 (100 μM) or vehicle for 1 h. The cytoplasmic levels of Bax, Bcl-2, Cyt C, cleaved-caspase-9, cleaved-caspase-3 and β-actin are measured by immunoblot assays in H9c2 cells.

    Bax inhibitor peptide V5 purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2018 Sep 15;355:269-285.  [Abstract]

    Bax inhibition ameliorates mitochondria dysfunction through modulating translocation and expression of Bax. H9c2 cells are treated with 160 nM TP for 24 h after pretreatment with BIP V5 (100 μM) or vehicle for 1 h. The mitochondrial levels of Bax, Bak, Bcl-2, Cyt C, and COX VI are measured by western blot analysis in H9c2 cells.

    Bax inhibitor peptide V5 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Jul 3;7(1):4546.  [Abstract]

    Pretreatment with BIP-V5 significantly rescues cells from apoptosis induced by HDAC6 inhibition, whereas no effect is detected with a negative control peptide.

    Bax inhibitor peptide V5 purchased from MedChemExpress. Usage Cited in: Université Laval. 2017-08.

    Apoptosis is measured using Annexin V staining (green) in control (n=3 cell lines) and PAH-PASMCs (n=3 cell lines) pre-treated or not with Bax inhibitory peptides (BIP-V5, 200μM) or control peptides before being exposed to indicated HDAC6 inhibitors for 48 hours. Representative immunofluorescence images of apoptotic Annexin-V-positive cells (green) stained for DAPI (blue) and corresponding quantification are shown.

    View All Bcl-2 Family Isoform Specific Products:

    View All Isoforms
    Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

    IC50 & Target[1]

    Bax

     

    In Vitro

    Bax inhibitor peptide V5 (BIP-V5; 0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bax inhibitor peptide V5 Related Antibodies
    In Vivo

    Bax inhibitor peptide V5 (BIP-V5; 100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    586.79

    Appearance

    Solid

    Formula

    C27H50N6O6S
    CAS No.
    Sequence Shortening

    VPMLK
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (170.42 mM)

    H2O : 100 mg/mL (170.42 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7042 mL 8.5209 mL 17.0419 mL
    5 mM 0.3408 mL 1.7042 mL 3.4084 mL
    10 mM 0.1704 mL 0.8521 mL 1.7042 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (170.42 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
    Cell Assay
    [1]

    Cells (2.5×104 cells/mL) are grown in 96-well plates in a final volume of 100 μL/well. After 24 h, cells are incubated with small molecules or vehicle (DMSO) for 48-96 h prior to harvest. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole (MTT) reagent (0.5 mg/mL), is added to each well during the final 2 h, and absorbance is measured. Cell growth is calculated as the ratio of absorbance obtained upon compound treatment to that obtained with vehicle (DMSO) treatment.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    Bax inhibitor peptide V5 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Bax inhibitor peptide V5579492-81-2BIP-V5 BAX Inhibiting Peptide V5Bax inhibitor peptide V 5Bax inhibitor peptide V-5BAX Inhibiting Peptide V5BAX Inhibiting Peptide V 5BAX Inhibiting Peptide V-5Bcl-2 FamilyApoptosisInhibitorinhibitorinhibit

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