1. Flavonoids

Genkwanin (Synonyms: Puddumetin)

Cat. No.: HY-N0731
Handling Instructions

Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.

For research use only. We do not sell to patients.

Genkwanin Chemical Structure

Genkwanin Chemical Structure

CAS No. : 437-64-9

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5 mg USD 60 Get quote
10 mg USD 90 Get quote
50 mg USD 270 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.

In Vitro

Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-N0731